Pajjiż: Malasja
Lingwa: Ingliż
Sors: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CHLORPHENIRAMINE MALEATE
HOVID BERHAD
CHLORPHENIRAMINE MALEATE
1000 Tablets; 100 Tablets; 100 Tablets
HOVID BERHAD
Please refer to E12. Aqra d-dokument sħiħ
HORAMINE DESCRIPTION Horamine Tablet: Round, yellow uncoated tablet, shallow convex faces; “HD” embossed and scored on the same face. Horamine Syrup: Red, raspberry flavoured viscous liquid. COMPOSITION Horamine Tablet: Each tablet contains Chlorpheniramine Maleate 4 mg. Horamine Syrup: Each 5 ml contains Chlorpheniramine Maleate 4 mg. PHARMACODYNAMICS Chlorpheniramine acts by competing with histamine for H1-receptor sites on effector cells, thus preventing responses mediated by histamine. Its antimuscarinic actions will provide a drying effect on the nasal mucosa. PHARMACOKINETICS Chlorpheniramine is readily absorbed after oral administration, metabolised in the liver and excreted mainly in the urine. It is widely distributes throughout the body tissues and appears to be subjected to enterohepatic circulation. It is metabolized in the liver to form polar and non-polar metabolites. INDICATIONS For symptomatic treatment of: Allergic or vasomotor rhinitis, hay fever, urticaria, angioneurotic oedema, sensitivity reactions and other itching skin conditions including pruritus ani, pruritus vulvae, pruritus of drug rashes, contact dermatitis and insect bites. CONTRAINDICATIONS • Avoid in patients known to be hypersensitive to antihistamines. • Use is not recommended in nursing mothers and in children below 6 years of age. WARNING AND PRECAUTIONS This medication may cause drowsiness in some patients. Caution when driving or operating machinery. Avoid alcoholic beverages. When used for treatment of cough and cold; (a) Not to be used in children less than 2 years of age (b) To be used with caution and doctor’s / pharmacist’s advice in children 2 to 6 years of age. PREGNANCY AND LACTATION Pregnancy: The risk-benefit must be considered, although no association between any fetal abnormalities has been formed with chlorpheniramine. Lactation: Small amount of chlorpheniramine are excreted in breast milk. Due to the higher risk of adverse effects of antihistamines in infants, the use of chlorpheniramine is not recom Aqra d-dokument sħiħ