Pajjiż: Awstralja
Lingwa: Ingliż
Sors: Department of Health (Therapeutic Goods Administration)
Pyrimethamine
1 DARAPRIM ® TABLETS _Pyrimethamine _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET? Please read this leaflet carefully before you take Daraprim tablets. This leaflet answers some common questions about Daraprim tablets. It does not contain all of the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the expected benefits of you taking Daraprim tablets against the risks this medicine could have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT ARE DARAPRIM TABLETS USED FOR? Daraprim tablets are used: to treat toxoplasmosis infections when taken with another antibiotic called a sulphonamide together with a folic acid supplement. Daraprim belongs to a group of medicines called antiprotozoals, which are used against infections of the blood caused by the parasites called _Plasmodium_ which causes a disease called toxoplasmosis. Daraprim tablets work by disrupting the way that proteins and genetic material are made inside the parasites. Your doctor may have prescribed Daraprim tablets for another reason. Please ask your doctor why Daraprim has been prescribed for you. Daraprim tablets are not addictive. BEFORE YOU TAKE DARAPRIM TABLETS _ _ _DO NOT TAKE IF: _ You must not take Daraprim tablets if: you have ever had an allergic reaction to pyrimethamine or any of the ingredients listed toward the end of this leaflet. (See “Ingredients”). THE EXPIRY DATE (EXP) PRINTED ON THE PACK HAS PASSED. THE PACKAGING IS TOR Aqra d-dokument sħiħ
1 PRODUCT INFORMATION DARAPRIM TABLETS NAME OF THE MEDICINE: Pyrimethamine The chemical name of pyrimethamine is 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, with a molecular formula C 12 H 13 ClN 4 and a molecular weight of 248.7. It is practically insoluble in water; slightly soluble in ethanol and dilute HCl. The chemical structure is: CAS NUMBER – 58-14-0 DESCRIPTION: Each tablet contains pyrimethamine 25mg as the active ingredient plus the inactive ingredients: lactose, maize starch, hydrolysed starch, docusate sodium and magnesium stearate. PHARMACOLOGY: Pyrimethamine is an inhibitor of the enzyme dihydrofolate reductase (DHFR). It blocks the reduction of dihydrofolic acid to tetrahydrofolic acid which is an essential coenzyme in the production of nucleic acids, thereby leading to disruption of protein synthesis and nuclear division. The affinity of pyrimethamine for protozoal DHFR is much greater than that for the mammalian enzyme. Sulphonamides act synergistically with pyrimethamine by arresting production of dihydrofolic acid from para-aminobenzoic acid. This results in sequential blockade of the folate pathway of Toxoplasma which, in contrast to man, is unable to utilise preformed folate. PHARMACOKINETICS: Peak plasma levels are found between 2 and 4 hours after oral administration of a 100 mg dose of pyrimethamine and the plasma half-life is approximately 90 hours. 87% of pyrimethamine is bound to plasma proteins and Aqra d-dokument sħiħ