AXCEL FLEMIN EXPECTORANT

Country: Malasja

Lingwa: Ingliż

Sors: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredjent attiv:

DIPHENHYDRAMINE HYDROCHLORIDE; AMMONIUM CHLORIDE

Disponibbli minn:

KOTRA PHARMA (M) SDN. BHD.

INN (Isem Internazzjonali):

DIPHENHYDRAMINE HYDROCHLORIDE; AMMONIUM CHLORIDE

Unitajiet fil-pakkett:

60ml mL; 100ml mL; 60 ml mL; 90 ml mL; 100 ml mL; 120 ml mL; 90 ml mL

Manifatturat minn:

KOTRA PHARMA (M) SDN. BHD.

Fuljett ta 'informazzjoni

AXCEL FLEMIN EXPECTORANT
Diphenhydramine Hydrochloride /Ammonium Chloride (12.5mg/130mg per
5ml)
_ _
1
_Consumer Medication Information Leaflet (RiMUP) _
WHAT IS IN THIS LEAFLET
1.
What Axcel Flemin Expectorant
is used for.
2.
How Axcel Flemin Expectorant
works.
3.
Before
you
use
Axcel
Flemin
Expectorant.
4.
How
to
use
Axcel
Flemin
Expectorant.
5.
While you are using it.
6.
Side effects.
7.
Storage
and
disposal
of
Axcel
Flemin Expectorant.
8.
Product description.
9.
Manufacturer
and
Product
Registration Holder.
10.
Date of revision.
WHAT AXCEL FLEMIN EXPECTORANT IS
USED FOR
Axcel Flemin Expectorant is used to
relief cough and alleviation of nasal
(nose) and bronchial (tubes that carry
air into the lungs) congestion.
HOW
AXCEL
FLEMIN
EXPECTORANT
WORKS
Diphenhydramine hydrochoride is a
histamine H1-receptor antagonist. It
is an antihistamine which works by
blocking a certain natural substance
(histamine)
that
your
body
makes
during an allergic reaction.
Ammonium chloride is used as an
expectorant.
It
helps
loosen
up
phlegm making it easier to cough it
up.
BEFORE
YOU
USE
AXCEL
FLEMIN
EXPECTORANT
_-When you must not use it _
Do
not
take
Axcel
Flemin
Expectorant if:
•
You
are
hypersensitive
to
diphenhydramine
or
other
antihistamines.
•
You
are
receiving
monoamine
oxidase inhibitors (MAOIs) (for
depression) therapy.
•
You are having impaired liver or
kidney function.
•
It is not prescribed by a qualified
doctor or pharmacist for you.
•
Do
not
take
Axcel
Flemin
Expectorant if you are pregnant,
trying to get pregnant or think
you may be pregnant.
•
Do
not
take
Axcel
Flemin
Expectorant
if
you
are
breast-
feeding.
Ask
your
doctor
or
pharmacist
for
advice
before
taking any medicine.
_-Before you start to use it _
Tell your doctor if:
•
You
are
having
narrow
angle
glaucoma (a buildup of pressure
in the eye), history of bronchial
asthma,
hyperthyroidism
(a
raised level of thyroid hormone),
cardiovascular (heart and blood
vessel)
disease
and
prostatic
hypertrophy (enlargement of the
prostate),
peptic
ulcer
(sore

Karatteristiċi tal-prodott

paraldehyde, thiopentone sodium, and chlorpromazine have
also been recommended. Severe hypotension may require fluid
replacement,
and
assisted
respiration
may
be
necessary.
Forced diuresis is of little value since antihistamines are rapidly
metabolized and only traces are recovered in the urine. Large
doses of Ammonium Chloride may cause a profound acidosis
and hypokalaemia which should be treated symptomatically.
STORAGE:
Keep container well closed.
Store below 30
o
C. Protect from light.
KEEP OUT OF REACH OF CHILDREN
JAUHI DARI KANAK-KANAK
PACK QUANTITIES:
Available in 60ml, 90ml, and 100ml PET bottle; 120ml amber
glass bottle.
Further information can be obtained from pharmacist, physician
or the manufacturer.
FLEMIN
EXPECTORANT
MAL19991903AZ
COMPOSITION:
Each 5ml contains
Diphenhydramine HCl 12.5mg
Ammonium Cl
130mg
Sodium Benzoate 0.1% w/v as preservative &
Sodium Citrate 60mg/5ml.
PRESENTATION:
Brown colour syrup with caramel flavour.
INDICATIONS:
Relief of cough & alleviate nasal & bronchial
congestion.
PHARMACOLOGY:
_Mechanism of action:_
Diphenhydramine
is
an
ethanolamines
antihistamine, a H1-receptor antagonist. It acts
by competing with histamine for H1-receptor
sites on the effectors cells, to the exclusion of
agonist
molecules,
without
itself
initiating
a
response. This antagonism is competitive and
reversible. It does not block the release of
histamine. Ammonium chloride is used as an
expectorant.
_Pharmacokinetic:_
Diphenhydramine
is
readily
absorbed
from
gastrointestinal
tract
and
parental
sites
of
administration. Systemic availability is affected
by high first-pass metabolism. Peak plasma
concentration
is
within
1-4
hours
after
oral
administration. It is highly bound to plasma
protein, thus widely distributed throughout the
body including the CNS. It crosses the placenta
and has been detected in breast milk. Most of
the diphenhydramine is excreted as metabolites
through urine with complete excretion within 24
hours. Ammonium chloride is absorbed from the
gastrointestinal
tract. The
ammonium
ion
is