Pajjiż: Awstralja
Lingwa: Ingliż
Sors: Department of Health (Therapeutic Goods Administration)
Perindopril erbumine
Apotex Pty Ltd
Medicine Registered
APO-PERINDOPRIL _Contains the active ingredient perindopril (per-in-do-pril) erbumine_ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about perindopril. It does not contain all the available information about this medicine. It does not take the place of talking to your doctor or pharmacist. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you taking this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is APO- Perindopril. It contains the active ingredient perindopril erbumine. Perindopril belongs to a group of medicines called angiotensin converting enzyme (ACE) inhibitors. It is used to treat high blood pressure, heart failure or stable coronary artery disease. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HIGH BLOOD PRESSURE_ Everyone has blood pressure. This pressure helps to circulate blood all around the body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have high blood pressure (also known as hypertension) when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are usually no symptoms of high blood pressure. The only way of knowing th Aqra d-dokument sħiħ
Product Information – Australia APO-Perindopril Page 1 APO-PERINDOPRIL TABLETS NAME OF THE MEDICINE Perindopril erbumine. Chemical Name: tert-butylammonium(2S,3aS,7aS)-1-N-[(S)-1-ethoxycarbonylbutyl] –L- alanyl)perhydroindole -2-carboxylate Structural Formula: Molecular Formula: C 19 H 32 N 2 O 5 ,C 4 H 11 N CAS Registry Number: 107133-36-8 DESCRIPTION Perindopril is a dipeptide monoacid monoester with a perhydroindole group and no sulfhydryl radical. Perindopril erbumine is a white powder, readily soluble in purified water, 95% ethanol and chloroform. Perindopril has five asymmetric centres. The drug is synthesised stereoselectively so that it is a single enantiomer (all S stereochemistry). Perindopril erbumine is an angiotensin converting enzyme inhibitor. PHARMACOLOGY MECHANISM OF ACTION Perindopril (prodrug), following hydrolysis to perindoprilat, inhibits angiotensin converting enzyme (ACE) both in vitro and in vivo. It is thought that ACE inhibitors reduce blood pressure by inhibiting the enzyme which catalyses the conversion of angiotensin I to angiotensin II. Decreased plasma angiotensin II leads to increased plasma renin activity and a decrease in aldosterone. In addition to its effects on circulating ACE, perindopril binds to and inhibits tissue converting enzyme, predominantly in the kidney and vascular wall. The contribution of this mechanism to the overall antihypertensive effect of perindopril is unknown. Animal studies have demonstrated reversal of vascular hypertrophy and an improvement in the ratio of elastin to collagen in the vessel wall. Studies in humans have demonstrate Aqra d-dokument sħiħ