APO-Perindopril

Country: Australia

Language: English

Source: Department of Health (Therapeutic Goods Administration)

Active ingredient:

Perindopril erbumine

Available from:

Apotex Pty Ltd

Class:

Medicine Registered

Patient Information leaflet

APO-PERINDOPRIL

_Contains the active ingredient perindopril (per-in-do-pril) erbumine_
CONSUMER MEDICINE INFORMATION

_FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about perindopril. It does
not contain all the available
information about this medicine. It
does not take the place of talking to
your doctor or pharmacist.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
You can also download the most up
to date leaflet from
www.apotex.com.au.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is APO-
Perindopril.
It contains the active ingredient
perindopril erbumine.
Perindopril belongs to a group of
medicines called angiotensin
converting enzyme (ACE) inhibitors.
It is used to treat high blood pressure,
heart failure or stable coronary artery
disease.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HIGH BLOOD PRESSURE_
Everyone has blood pressure. This
pressure helps to circulate blood all
around the body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
high blood pressure (also known as
hypertension) when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
high blood pressure. The only way of
knowing th

Summary of Product characteristics

Product Information 
– Australia 
APO-Perindopril 
Page 1 
APO-PERINDOPRIL TABLETS 

NAME OF THE MEDICINE 
Perindopril erbumine. 

Chemical Name:  
tert-butylammonium(2S,3aS,7aS)-1-N-[(S)-1-ethoxycarbonylbutyl]
–L-
alanyl)perhydroindole -2-carboxylate  

Structural Formula: 

Molecular Formula:  
C
19
H
32
N
2
O
5
,C
4
H
11
N  

CAS Registry Number: 107133-36-8 

DESCRIPTION 

Perindopril  is  a  dipeptide  monoacid  monoester  with  a  perhydroindole  group  and  no  sulfhydryl  radical. 
Perindopril  erbumine  is  a  white  powder,  readily  soluble  in  purified  water,  95%  ethanol  and  chloroform. 
Perindopril  has  five  asymmetric  centres. The  drug  is  synthesised  stereoselectively  so  that  it  is  a  single 
enantiomer (all S stereochemistry). 

Perindopril erbumine is an angiotensin converting enzyme inhibitor. 

PHARMACOLOGY 
MECHANISM OF ACTION 
Perindopril (prodrug), following hydrolysis to perindoprilat, inhibits angiotensin converting enzyme (ACE) 
both in vitro and in vivo. It is thought that ACE inhibitors reduce blood pressure by inhibiting the enzyme 
which catalyses the conversion of angiotensin I to angiotensin II. Decreased plasma angiotensin II leads 
to increased plasma renin activity and a decrease in aldosterone. In addition to its effects on circulating 
ACE, perindopril binds to and inhibits tissue converting enzyme, predominantly in the kidney and vascular 
wall. The contribution of this mechanism to the overall antihypertensive effect of perindopril is unknown. 
Animal studies have demonstrated reversal of vascular hypertrophy and an improvement in the ratio of 
elastin  to  collagen  in  the  vessel  wall.    Studies  in  humans  have  demonstrate