ZYLTAN 50 (Losartan Potassium Tablets USP 50mg)

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

LOSARTAN POTASSIUM

Boleh didapati daripada:

UNIMED SDN BHD

INN (Nama Antarabangsa):

LOSARTAN POTASSIUM

Unit dalam pakej:

10x10tablet Tablets

Dikeluarkan oleh:

Troikaa Pharmaceuticals Ltd

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
ZYLTAN 50
Losartan potassium tablets USP 50 mg
WHAT IS IN THIS LEAFLET
1.
What Zyltan 50 is used for
2.
How Zyltan 50 works
3.
Before you use Zyltan 50
4.
How to use Zyltan 50
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Zyltan 50
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT ZYLTAN 50 IS USED FOR
Zyltan lowers high blood pressure, which
doctors call hypertension. It is also used
to slow the progression of kidney disease
in
people
who
have
type
2
diabetes
mellitus with protein in their urine.
HOW ZYLTAN 50 WORKS
Zyltan belongs to a group of medicines,
called angiotensin I I receptor antagonists.
It works to lower your blood pressure by
relaxing your blood vessels. In addition, it
slows the progression of kidney disease in
people who have type 2 diabetes mellitus
with protein in the urine.
BEFORE YOU USE ZYLTAN 50
-
_When you must not use it _
_ _
Do not take Zyltan 50 if:
•
You are pregnant or breast- feeding.
•
You have an allergy to Zyltan or any
ingredients of it.
•
The packaging is torn or shows signs
of tampering.
•
The expiry date on the pack has
passed.
-
_Before you start use it _
_ _
Tell your doctor if:
•
You intend to become pregnant or
plan to breast-feed.
•
You
have
had
any
medical
conditions. You have recently had
excessive vomiting or diarrhoea.
•
You have any allergies to any other
medicines or any other substances. If
you have not told your doctor about
any of the above, tell them before you
take Zyltan.
-
_Taking other medicines _
Tell your doctor if you are taking any
other medicines, including medicines that
you
buy
without
a
prescription.
Your
doctor
or
pharmacist
has
more
information on medicines to be careful
with or avoid while taking Zyltan.
HOW TO USE ZYLTAN 50
-
_How much to use _
_ _
Your
doctor
will
tell
you
how
many
tablets you need to take each day. This
depends on your condition and whether
you are taking other medicines.
Treatment usually star

Ciri produk

FRONT
Prescribing Information
For the use of Registered Medical
Practitioner, Hospital or a Laboratory Only.
White colored, oblong shaped, film coated tablets having a break line
on
one side. ZYLTAN (Losartan potassium) is an angiotensin II receptor
(type AT )antagonist.
1
Each film coated tablet contains:
Mechanism of Action
Angiotensin II [formed from angiotensin I in a reaction catalyzed by
angiotensin converting enzyme (ACE, kininase II)], is a potent
vasoconstrictor, the primary vasoactive hormone of the
renin-angiotensin
system and an important component in the pathophysiology of
hypertension. It also stimulates aldosterone secretion by the adrenal
cortex. Losartan and its principal active metabolite block the
vasoconstrictor and aldosterone-secreting effects of angiotensin II by
selectively blocking the binding of angiotensin II to the AT1 receptor
found
in many tissues, (e.g., vascular smooth muscle, adrenal gland). There
is
also an AT2 receptor found in many tissues but it is not known to be
associated with cardiovascular homeostasis. Both Losartan and its
principal active metabolite do not exhibit any partial agonist
activity at the
AT1 receptor and have much greater affinity (about 1000-fold) for the
AT1
receptor than for the AT2 receptor. In vitro binding studies indicate
that
Losartan is a reversible, competitive inhibitor of the AT1 receptor.
The
active metabolite is 10 to 40 times more potent by weight than
Losartan
and appears to be a reversible, non-competitive inhibitor of the AT1
receptor.
Neither Losartan nor its active metabolite inhibits ACE (kininase II,
the
enzyme that converts angiotensin I to angiotensin II and degrades
bradykinin); nor do they bind to or block other hormone receptors or
ion
channels known to be important in cardiovascular regulation.
COMPOSITION :
Pharmacodynamics and Clinical Effects
CLINICAL PHARMACOLOGY :
Losartan Potassium USP 50 mg.
DESCRIPTION :
The effect of Losartan is substantially present within one week but in
some studies the maximal effect occurred in 3-6 w