Country: Malaysia
Language: English
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
LOSARTAN POTASSIUM
UNIMED SDN BHD
LOSARTAN POTASSIUM
10x10tablet Tablets
Troikaa Pharmaceuticals Ltd
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ ZYLTAN 50 Losartan potassium tablets USP 50 mg WHAT IS IN THIS LEAFLET 1. What Zyltan 50 is used for 2. How Zyltan 50 works 3. Before you use Zyltan 50 4. How to use Zyltan 50 5. While you are using it 6. Side effects 7. Storage and Disposal of Zyltan 50 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT ZYLTAN 50 IS USED FOR Zyltan lowers high blood pressure, which doctors call hypertension. It is also used to slow the progression of kidney disease in people who have type 2 diabetes mellitus with protein in their urine. HOW ZYLTAN 50 WORKS Zyltan belongs to a group of medicines, called angiotensin I I receptor antagonists. It works to lower your blood pressure by relaxing your blood vessels. In addition, it slows the progression of kidney disease in people who have type 2 diabetes mellitus with protein in the urine. BEFORE YOU USE ZYLTAN 50 - _When you must not use it _ _ _ Do not take Zyltan 50 if: • You are pregnant or breast- feeding. • You have an allergy to Zyltan or any ingredients of it. • The packaging is torn or shows signs of tampering. • The expiry date on the pack has passed. - _Before you start use it _ _ _ Tell your doctor if: • You intend to become pregnant or plan to breast-feed. • You have had any medical conditions. You have recently had excessive vomiting or diarrhoea. • You have any allergies to any other medicines or any other substances. If you have not told your doctor about any of the above, tell them before you take Zyltan. - _Taking other medicines _ Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription. Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking Zyltan. HOW TO USE ZYLTAN 50 - _How much to use _ _ _ Your doctor will tell you how many tablets you need to take each day. This depends on your condition and whether you are taking other medicines. Treatment usually star Read the complete document
FRONT Prescribing Information For the use of Registered Medical Practitioner, Hospital or a Laboratory Only. White colored, oblong shaped, film coated tablets having a break line on one side. ZYLTAN (Losartan potassium) is an angiotensin II receptor (type AT )antagonist. 1 Each film coated tablet contains: Mechanism of Action Angiotensin II [formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II)], is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland). There is also an AT2 receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. Both Losartan and its principal active metabolite do not exhibit any partial agonist activity at the AT1 receptor and have much greater affinity (about 1000-fold) for the AT1 receptor than for the AT2 receptor. In vitro binding studies indicate that Losartan is a reversible, competitive inhibitor of the AT1 receptor. The active metabolite is 10 to 40 times more potent by weight than Losartan and appears to be a reversible, non-competitive inhibitor of the AT1 receptor. Neither Losartan nor its active metabolite inhibits ACE (kininase II, the enzyme that converts angiotensin I to angiotensin II and degrades bradykinin); nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation. COMPOSITION : Pharmacodynamics and Clinical Effects CLINICAL PHARMACOLOGY : Losartan Potassium USP 50 mg. DESCRIPTION : The effect of Losartan is substantially present within one week but in some studies the maximal effect occurred in 3-6 w Read the complete document