Panosec Tablet 20mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

PANTOPRAZOLE SODIUM SESQUIHYDRATE

Boleh didapati daripada:

Duopharma Marketing Sdn. Bhd.

INN (Nama Antarabangsa):

PANTOPRAZOLE SODIUM SESQUIHYDRATE

Unit dalam pakej:

50x10 Tablets; 10x10 Tablets; 9x10 Tablets; 6x10 Tablets; 1x10 Tablets; 3x10 Tablets

Dikeluarkan oleh:

Hetero Labs Limited

Risalah maklumat

Consumer Medication Information Leaflet (RiMUP)
1
PANOSEC TABLET 20MG
Pantoprazole Sodium Sesquihydrate
WHAT IS IN THIS LEAFLET
1.
What Panosec Tablet 20mg is
used for
2.
How Panosec Tablet 20mg
works
3.
Before you use Panosec Tablet
20mg
4.
How to take Panosec Tablet
20mg
5.
While you are using Panosec
Tablet 20mg
6.
Side Effects
7.
Storage and Disposal of
Panosec Tablet 20mg
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of Revision
1.
WHAT PANOSEC TABLET 20MG
IS USED FOR
Panosec Tablet 20mg is used:
•
To treat symptoms (e.g.
heartburn, acid
regurgitation, pain on
swallowing) associated with
mild reflux disease caused
by reflux of acid from the
stomach.
•
For the long-term
management and prevention
of reflux oesophagitis from
coming back.
•
For the prevention of
stomach and duodenal
ulcers caused by non-
steroidal anti- inflammatory
drugs (NSAIDs), in people
at risk who need to take
NSAIDs continuously.
2.
HOW PANOSEC TABLET 20MG
WORKS
Panosec Tablet 20mg is a
selective “proton pump
inhibitor”, a medicine which
reduces the amount of acid
produced in your stomach
3.
BEFORE YOU USE PANOSEC TABLET
20MG
_When you must not take it _
Do not take Panosec Tablet
20mg:
•
if you are allergic
(hypersensitive) to pantoprazole
or any of the other ingredients of
Panosec Tablet 20mg
.
•
if you are allergic to medicines
containing other proton pump
inhibitors.
•
Tell your doctor before taking
this medicine, if you are due to
have a specific blood test
(Chromogranin A)
_Before you start to take it_
Take special care with Panosec
Tablet 20mg
•
If you have severe liver
problems. Please tell your doctor
if you have ever had problems
with your liver. Doctor will
check your liver enzymes more
frequently, especially when you
are taking Panosec Tablet 20mg
as a long- term treatment.
•
If you need to take medicines
called NSAIDs continuously with
prescribed Panosec Tablet 20mg.
you might have an increased risk
of developing stomach and
intestinal complication.
•
If you have reduced

Ciri produk

PANOSEC TABLET 20MG
NAME OF PRODUCT
Pantoprazole Gastro-Resistance Tablet 20mg
NAME AND STRENGTH OF ACTIVE INGREDIENT
NAME
: Pantoprazole Sodium Sesquihydrate
STRENGTH
: 20mg
ROUTE OF ADMINISTRATION: ORAL
PRODUCT DESCRIPTION
Yellow to pale yellow, oval, biconvex gastro resistant tablets
imprinted‘H125’ on one side with
black ink and plain on the other side.
PHARMACODYNAMICS
MECHANISM OF ACTION
Pantoprazole is a substituted benzimidazole which inhibits the
secretion of hydrochloric acid
in the stomach by specific blockade of the proton pumps of the
parietal cells. Pantoprazole is
converted to its active form in the acidic environment in the parietal
cells where it inhibits the
H+, K+-ATPase enzyme, i.e. the final stage in the production of
hydrochloric acid in the
stomach.
The
inhibition
is
dose- dependent
and
affects both
basal
and stimulated acid
secretion. In most patients, freedom from symptoms is achieved within
2 weeks. As with other
proton pump inhibitors and H2 receptor inhibitors, treatment with
pantoprazole reduces
acidity in the stomach and thereby increases gastrin in proportion to
the reduction in acidity.
The increase in gastrin is reversible. Since pantoprazole binds to the
enzyme distal to the cell
receptor level, it can inhibit hydrochloric acid secretion
independently of stimulation by other
substances (acetylcholine, histamine, gastrin). The effect is the same
whether the product is
given orally or intravenously. The fasting gastrin values increase
under pantoprazole. On short-
term use, in most cases they do not exceed the upper limit of normal.
During long-term
treatment, gastrin levels double in most cases. An excessive increase,
however, occurs only in
isolated cases. As a result, a mild to moderate increase in the number
of specific endocrine
(ECL) cells in the stomach is observed in a minority of cases during
long term treatment (simple
to adenomatoid hyperplasia).
During treatment with antisecretory medicinal products, serum gastrin
increases in response
to the decreased gastric acidi