Country: Kanada
Bahasa: Inggeris
Sumber: Health Canada
TRIMEPRAZINE (TRIMEPRAZINE TARTRATE)
SEARCHLIGHT PHARMA INC
R06AD01
ALIMEMAZINE
2.5MG
TABLET
TRIMEPRAZINE (TRIMEPRAZINE TARTRATE) 2.5MG
ORAL
100
Prescription
PHENOTHIAZINE DERIVATIVES
Active ingredient group (AIG) number: 0106200001; AHFS:
APPROVED
2000-11-06
PRODUCT MONOGRAPH PR PANECTYL TRIMEPRAZINE TARTRATE TABLETS 2.5 MG AND 5 MG TRIMEPRAZINE (AS TRIMEPRAZINE TARTRATE) TABLETS MANUFACTURER STANDARD ANTIPRURITIC - ANTIHISTAMINIC Searchlight Pharma Inc. 1600 Notre-Dame West, suite 312 Montreal, Quebec H3J 1M1 Date of Preparation: OCT 17, 2022 Submission Control No.: 267388 2 STRUCTURAL FORMULA AND CHEMISTRY Neutral tartrate of 10-[3-(2-methyl) dimethylaminopropyl] phenothiazine. Its structural formula may be represented as follows: White, non hygroscopic, light-sensitive, crystalline powder. Melting range, between 160 and 164 C. Freely soluble in water, soluble in alcohol, sparingly soluble in chloroform and very slightly soluble in ether and benzene. Molecular weight : 746.97 ACTION Panectyl is a phenothiazine derivative with reduced central activity and enhanced antihistaminic and antipruritic effects. It has marked sedative, antiserotonin, antispasmodic and antiemetic properties but has only a weak effect on the autonomic nervous system. INDICATIONS _Pruritus _regardless of site or etiology such as may occur in : neurodermatitis, eczema, urticaria, pruritus ani, pruritus vulvae, drug eruption, dermatitis herpetiformis, insect bites, contact dermatitis; pruritus due to non-dermatological conditions : chicken pox, measles, Hodgkin’s disease, obstructive jaundice, diabetes, zona. _Cough _ of various etiologies such as may occur in : acute or chronic conditions of the upper respiratory tract, persistent cough, bronchial irritation, whooping cough, asthma-like dyspnea, asthma, hay fever. 3 CONTRAINDICATIONS States of CNS depression due to barbiturates, alcohol, narcotics or analgesics. Cases with a history of blood dyscrasias or severe allergic reactions related to trimeprazine or other phenothiazines. Trimeprazine is contraindicated for use in children less than two years of age. (see Warnings section). WARNINGS Patients should be advised against driving or engaging in activities requiring complete mental alertness or physical co-ordination, until their res Baca dokumen lengkap