MK essentia healthcare series Pain Relief cream

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Methyl salicylate; Menthol

Boleh didapati daripada:

MegaLive BioSciences Sdn Bhd

INN (Nama Antarabangsa):

Methyl salicylate; Menthol

Unit dalam pakej:

30 gm

Dikeluarkan oleh:

SYARIKAT WEN KEN DRUG SDN. BHD.

Risalah maklumat

MK ESSENTIA HEALTHCARE SERIES PAIN
RELIEF CREAM
Menthol 6%w/w, Methyl Salicylate 13%w/w
1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What Pain Relief Cream is used for
2.
How Pain Relief Cream works
3.
Before you use Pain Relief Cream
4.
How to use Pain Relief Cream
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Pain Relief
Cream
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
11.
Serial Number
WHAT PAIN RELIEF CREAM IS USED FOR
Temporary pain relief for neck, shoulder
aches, stressed, tired and stiff muscles.
HOW PAIN RELIEF CREAM WORKS
It contains methyl salicylate and
menthol. Menthol_ _dilates the blood
vessels causing a sensation of coldness,
followed by an analgesic effect. Menthol
also acts as a penetration enhancer,
increasing the penetration of drugs when
applied on the skin, to give a faster onset
of action. Methyl salicylate is used
topically as a counter irritant. Upon
application, it is absorbed through the
skin and is applied for the relief of
rheumatic pain and muscle or joints pain.
BEFORE YOU USE PAIN RELIEF CREAM
- _When you must not use it_
Do not use in patients with aspirin or
salicylate idiosyncrasy.
Do not use it if you are allergic to any
ingredients of this Pain Relief Cream.
- _Before you start to use it_
Initially apply a small amount to a
limited skin area and observe whether
there is discomfort or itch before
applying to a larger skin area.
Discontinue use if irritation develops._ _
Please follow the advice of the doctor or
pharmacist.
- _Taking other medicines _
Please inform the doctor or pharmacist if
taking other medicines.
For patients taking warfarin, excessive
application on to the skin for muscle or
joint pains may increase the chances of
bleeding.
HOW TO USE PAIN RELIEF CREAM
- _How much to use_
Gently massage a sufficient amount of
the cream onto affected area.
For external use only.
Follow all directions given to you by
your doctor and pharmacist carefully.
They may differ fr

Ciri produk

MK ESSENTIA HEALTHCARE SERIES PAIN RELIEF CREAM
ACTIVE INGREDIENTS: Menthol 6%w/w, Methyl Salicylate
13%w/w
PRESERVATIVE: Chlorocresol 0.2%w/w
PRODUCT DESCRIPTION:
White colour, smooth application, sticky and characteristic
odor cream.
INDICATION:
For the symptomatic relief of muscular aches and pains, and
stiffness including backache, lumbago and fibrositis.
DIRECTION OF USE:
Gently massage a sufficient amount of the cream onto affected
area. Not recommended for children below 12 years old.
ROUTE OF ADMINISTRATION: Topical
PHARMACODYNAMICS
_Menthol_
Menthol dilates the blood vessels causing a sensation of
coldness, followed by an analgesic effect. Menthol also acts as
a penetration enhancer, increasing the penetration of drugs
when applied on the skin, to give a faster onset of action.
_Methyl Salicylate_
Methyl salicylate is a salicylic acid derivative. Salicylates inhibit
cyclooxygenase, thereby reducing the formation of prostaglan-
dins and cause platelet dysfunction. Methyl salicylate is used
topically as a counter irritant. Upon application, it is absorbed
through the skin and is applied for the relief of the pain in
rheumatic conditions and painful muscle or joints.
PHARMACOKINETICS
_Menthol_
After absorption, menthol is excreted in the urine and bile as a
glucuronide.
_Methyl Salicylate_
May be absorbed through intact skin. The absorption of topical
salicylates is proportional to the surface area involved, duration
of exposure, concentration and skin integrity. Absorption
characteristics of salicylates vary with the dose, formulation and
route of administration. Percutaneous absorption is enhanced by
exercise, heat, occlusion or disruption of the integrity of the skin
or application to large areas of skin. Both the rate and extent of
absorption increases after repeated application; increasing the
bioavailability. Methyl salicylate is extensively metabolised to
salicylic acid in the dermal and subcutaneous tissues after topical
application. At therapeutic levels, the half-life of salicylates is
2–
4