Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
LITHIUM CARBONATE
MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.
LITHIUM CARBONATE
1000 Tablets
MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.
_Consumer Medication Information Leaflet (RiMUP) _ 1 LICONATE TABLET Lithium Carbonate (300mg) WHAT IS IN THIS LEAFLET: 1. What Liconate Tablet is used for 2. How Liconate Tablet works 3. Before you use Liconate Tablet 4. How to use Liconate Tablet 5. While you are using Liconate Tablet 6. Side Effects 7. Storage and Disposal of Liconate Tablet 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT LICONATE TABLET IS USED FOR Lithium Carbonate is the active ingredient of Liconate Tablet. It is indicated for the prophylaxis and treatment of hypomania (a less severe form of mania) or mania (excitement manifested by mental and physical hyperactivity, disorganization of behavior, and elevation of mood), in the prophylaxis of manic depression (bipolar illness or bipolar depression) and recurrent depression (unipolar illness or unipolar depression). HOW LICONATE TABLET WORKS? The mechanism of anti-manic effects is unknown; lithium ions may act by competing with sodium ions at various sites in the body. BEFORE YOU USE LICONATE TABLET _- When you must not use it _ If you have severe kidney disease, debilitated or dehydrated and sodium depeletion. If you have cardiovascular disease and hypothyroidism (a condition in which the body lacks sufficient thyroid hormone) and also Addison Disease (a disorder that occurs when the adrenal glands do not produce enough hormones). If you or your child is under 12 years of age. If you are taking diuretic medicines. If you have hypersensitivity (allergic) to lithium carbonate or its ingredient. _- Before you start to use it _ You must tell your doctor if: you have allergies to any medicine which you have usen previously to treat your current condition. you are pregnant, trying to become pregnant or breast-feeding. Do not take Liconate Tablet until you and your doctor have discussed the risks and benefits involved. _- Taking other medicines _ Always inform your doctor and pharmacist if you are taking any other medicine Baca dokumen lengkap
7038-05 LICONATE TABLETS 300MG NAME AND STRENGTH OF ACTIVE INGREDIENT(S): Each tablet contains: Lithium Carbonate …………………………………………………300mg PRODUCT DESCRIPTION: A white, flat of diameter 11mm round tablet with ‘MPI’ logo. PHARMACODYNAMICS : Lithium possesses anti-manic effects but the mechanism is unknown; lithium ions may act by competing with sodium ions at various sites in the body. PHARMACOKINETICS: Lithium is readily and completely absorbed from the gastro-intestinal tract when taken as one of its salts. Absorption can be affected by the formulation of preparation taken. Peak serum concentrations are obtained between 0.5 and 3 hours after ingestion from conventional tablets. Lithium is distributed throughout the body and distribution is complete within 6 to 10 hours; higher concentration occur in the bones, the thyroid gland, and portions of the brain, than in the serum. Lithium is excreted predominantly in the urine; only a small amount can be detected in the faeces, saliva and sweat. It is not bound to plasma proteins. It crosses the placenta and is excreted in breast milk. In patients with normal renal function the average elimination half-life is about 20 to 24 hours. INDICATION: It is used in the prophylaxis and treatment of mania or hypomania, in the prophylaxis of manic depression (bipolar illness or bipolar depression ) and recurrent depression (unipolar illness or unipolar depression). RECOMMENDED DOSAGE: To be take orally. This medication may be taken with food, to minimize stomach upset. _Acute treatment of mania and hypomania : _ 1.5 – 2g daily may be given in divided doses for the first 5 to 7 days, together with close checks on serum-lithium concentrations, a higher concentration, often up to 1.5 mmol/L may be required. The dose may need to be reduced rapidly once the acute phase has passed. _Prophylactic therapy : _ The usual dose is 0.5 – 1.2g daily in divided doses. During the initial stages of lithium therapy, serum-lithium concentration must be Baca dokumen lengkap