Hovid Paracetamol and Orphenadrine Citrate Tablet 450mg35mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Paracetamol; ORPHENADRINE CITRATE

Boleh didapati daripada:

Hovid Pharmacy Sdn. Bhd.

INN (Nama Antarabangsa):

Paracetamol; ORPHENADRINE CITRATE

Unit dalam pakej:

500 Tablets; 1000 Tablets; 100 Tablets

Dikeluarkan oleh:

HOVID BERHAD

Ciri produk

DESCRIPTION
Round, 12 mm diameter, white to off-white uncoated tablet,
bevel edged, flat faces, “HD” embossed and scored on the
same face.
COMPOSITION
Each tablet contains:
Paracetamol
450 mg
Orphenadrine citrate
35 mg
PHARMACODYNAMICS
PARACETAMOL
Paracetamol is an analgesic and antipyretic. It may act by
inhibiting prostaglandin synthesis in the central nervous
system (CNS) and through a peripheral action by blocking
pain-impulse generation. The peripheral action may also be
due to inhibition to the synthesis of prostaglandins or to
inhibition of the synthesis or actions or other substances,
which sensitize pain receptors to mechanical or chemical
stimulation.
ORPHENADRINE
Orphenadrine is a skeletal muscle relaxant. The precise
mechanism of action of orphenadrine is unknown. It may act
in the central nervous system (CNS) to depress polysynaptic
reflexes. Its skeletal muscle relaxant properties may be
related to its CNS depressant (sedative) or to its analgesic
effects. It also has weak antihistaminic and local anesthetic
properties.
PHARMACOKINETICS
Paracetamol is absorbed rapidly and almost completely
following administration; may be decreased if taken following
a high-carbohydrate meal.
Orphenadrine is readily absorbed from the gastro-intestinal
tract. Being metabolized in liver the liver and most of the
dose is excreted in the urine along with a small proportion of
unchanged drug.
INDICATION
For
relief
of
tension
headache,
occipital
headaches
associated with spasm of skeletal muscles in the region of
the head and neck. Acute and traumatic conditions of the
limbs and trunk: sprains, strains, whiplash injuries, acute
torticollis, prolapsed intervertebral disc.
CONTRAINDICATIONS
Glaucoma,
prostatic
hypertrophy
or
obstruction
at
the
bladder neck, myasthenia gravis, oesophageal spasm and
pyloric or duodenal obstruction.
Hypersensitivity to paracetamol or orphenadrine citrate.
WARNING AND PRECAUTIONS
This preparation contains PARACETAMOL. Do not take any
other paracetamol containing medicines at the same time.