Country: Malaysia
Language: English
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol; ORPHENADRINE CITRATE
Hovid Pharmacy Sdn. Bhd.
Paracetamol; ORPHENADRINE CITRATE
500 Tablets; 1000 Tablets; 100 Tablets
HOVID BERHAD
DESCRIPTION Round, 12 mm diameter, white to off-white uncoated tablet, bevel edged, flat faces, “HD” embossed and scored on the same face. COMPOSITION Each tablet contains: Paracetamol 450 mg Orphenadrine citrate 35 mg PHARMACODYNAMICS PARACETAMOL Paracetamol is an analgesic and antipyretic. It may act by inhibiting prostaglandin synthesis in the central nervous system (CNS) and through a peripheral action by blocking pain-impulse generation. The peripheral action may also be due to inhibition to the synthesis of prostaglandins or to inhibition of the synthesis or actions or other substances, which sensitize pain receptors to mechanical or chemical stimulation. ORPHENADRINE Orphenadrine is a skeletal muscle relaxant. The precise mechanism of action of orphenadrine is unknown. It may act in the central nervous system (CNS) to depress polysynaptic reflexes. Its skeletal muscle relaxant properties may be related to its CNS depressant (sedative) or to its analgesic effects. It also has weak antihistaminic and local anesthetic properties. PHARMACOKINETICS Paracetamol is absorbed rapidly and almost completely following administration; may be decreased if taken following a high-carbohydrate meal. Orphenadrine is readily absorbed from the gastro-intestinal tract. Being metabolized in liver the liver and most of the dose is excreted in the urine along with a small proportion of unchanged drug. INDICATION For relief of tension headache, occipital headaches associated with spasm of skeletal muscles in the region of the head and neck. Acute and traumatic conditions of the limbs and trunk: sprains, strains, whiplash injuries, acute torticollis, prolapsed intervertebral disc. CONTRAINDICATIONS Glaucoma, prostatic hypertrophy or obstruction at the bladder neck, myasthenia gravis, oesophageal spasm and pyloric or duodenal obstruction. Hypersensitivity to paracetamol or orphenadrine citrate. WARNING AND PRECAUTIONS This preparation contains PARACETAMOL. Do not take any other paracetamol containing medicines at the same time. Read the complete document