Folina Tablets 15mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Calcium Folinate

Boleh didapati daripada:

PHARM-D SDN. BHD.

INN (Nama Antarabangsa):

Calcium Folinate

Unit dalam pakej:

100tablet Tablets

Dikeluarkan oleh:

TTY Biopharm Company Limited Lioudu Factory

Risalah maklumat

FOLINA TABLETS 15MG
Calcium Folinate 16.21mg (equivalent to Folinic Acid 15.0 mg)
1
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
WHAT IS IN THIS LEAFLET
1.
What Folina Tablets 15mg is used
for
2.
How Folina Tablets 15mg works
3.
Before you use Folina Tablets
15mg
4.
How to use Folina Tablets 15mg
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Folina
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
WHAT FOLINA TABLETS 15MG IS USED FOR
Calcium folinate is indicated:
- to diminish the toxicity and
counteract the action of folic acid
antagonist such as methotrexate in
cytotoxic therapy and overdose in
adults and children. In cytotoxic
therapy, this procedure is commonly
known as ‘Calcium folinate rescue’.
- In combination with 5- fluorouracil
for the treatment of colorectal carcinoma.
HOW FOLINA TABLETS 15MG WORKS
Folinate is a derivative of
tetrahydrofolic acid, the reduced form
of folic acid, which is involved as a
cofactor for 1-carbon transfer reactions
in the biosynthesis of purine and
pyrimidines of nucleic acids.
Impairment of thymidylate synthesis in
patients with folic acid deficiency is
thought to account for the defective
DNA synthesis that leads to
megaloblast formation and
megaloblastic and macrocytic anemias.
Because of its ready conversion to
other tetrahydrofolic acid derivatives,
Folinate is a potent antidote for both
hematopoietic and reticuloendothelia
toxic effects of folic acid antagonists,
(e.g. Methotrexate, Pyrimethamine,
Trimethoprim). It is postulated that in
some cancers, Folinate enters and
"rescues" normal cells from the toxic
effects of folic acid antagonists, in
preference to tumour cells, because of
a difference in membrane transport
mechanisms; this principle is the basis
of high-dose Methotrexate therapy
with "Folinate rescue".
BEFORE YOU USE FOLINA TABLETS 15MG
-
_When you must not use it_
PREGNANCY AND LACTATION
Reproduction studies have been
performed in rats and rabbits at doses
of at least 50 times the hum