Country: Malasía
Tungumál: enska
Heimild: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Calcium Folinate
PHARM-D SDN. BHD.
Calcium Folinate
100tablet Tablets
TTY Biopharm Company Limited Lioudu Factory
FOLINA TABLETS 15MG Calcium Folinate 16.21mg (equivalent to Folinic Acid 15.0 mg) 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Folina Tablets 15mg is used for 2. How Folina Tablets 15mg works 3. Before you use Folina Tablets 15mg 4. How to use Folina Tablets 15mg 5. While you are using it 6. Side effects 7. Storage and Disposal of Folina 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT FOLINA TABLETS 15MG IS USED FOR Calcium folinate is indicated: - to diminish the toxicity and counteract the action of folic acid antagonist such as methotrexate in cytotoxic therapy and overdose in adults and children. In cytotoxic therapy, this procedure is commonly known as ‘Calcium folinate rescue’. - In combination with 5- fluorouracil for the treatment of colorectal carcinoma. HOW FOLINA TABLETS 15MG WORKS Folinate is a derivative of tetrahydrofolic acid, the reduced form of folic acid, which is involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids. Impairment of thymidylate synthesis in patients with folic acid deficiency is thought to account for the defective DNA synthesis that leads to megaloblast formation and megaloblastic and macrocytic anemias. Because of its ready conversion to other tetrahydrofolic acid derivatives, Folinate is a potent antidote for both hematopoietic and reticuloendothelia toxic effects of folic acid antagonists, (e.g. Methotrexate, Pyrimethamine, Trimethoprim). It is postulated that in some cancers, Folinate enters and "rescues" normal cells from the toxic effects of folic acid antagonists, in preference to tumour cells, because of a difference in membrane transport mechanisms; this principle is the basis of high-dose Methotrexate therapy with "Folinate rescue". BEFORE YOU USE FOLINA TABLETS 15MG - _When you must not use it_ PREGNANCY AND LACTATION Reproduction studies have been performed in rats and rabbits at doses of at least 50 times the hum Lestu allt skjalið