Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PSEUDOEPHEDRINE HYDROCHLORIDE; Paracetamol; DEXTROMETHORPHAN HYDROBROMIDE
HOVID BERHAD
PSEUDOEPHEDRINE HYDROCHLORIDE; Paracetamol; DEXTROMETHORPHAN HYDROBROMIDE
100Capsule Capsules; 8Capsule Capsules
HOVID BERHAD
026 FLUCOR DAY WIFLUxx-0 (MY) DESCRIPTION Oblong, pink soft gelatin capsule filled with transparent liquid. COMPOSITION Each soft gelatin capsule contains: Paracetamol 250.0 mg Dextromethorphan HBr 10.0 mg Pseudoephedrine HC _l_ 30.0 mg ACTIONS AND PHARMACOLOGY Paracetamol, as an analgesic, may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and, to a lesser extent, through a peripheral action by blocking pain-impulse generation. The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation. Paracetamol probably produces antipyresis by acting centrally on the hypothalamic heat-regulating center to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating, and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the hypothalamus. Pseudoephedrine acts on alpha-adrenergic receptors in the mucosa of the respiratory tract, producing vasoconstriction. The medication shrinks swollen nasal mucous membranes; reduces hyperemia, edema, and nasal congestion; and increases nasal airway patency. Also drainage of sinus secretions may be increased and obstructed Eustachian ostia may be opened. Dextromethorphan suppresses the cough reflex by a direct action on the cough center in the medulla of the brain. PHARMACOKINETICS Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 10 to 60 minutes after oral administration and is distributed into most body tissues. The elimination half-life of paracetamol varies from about 1 to 3 hours. It is metabolized predominantly in the liver and excreted in the urine mainly as the glucoronide and sulphate conjugates, less than 5% is excreted as unchanged paracetamol. Pseudoephedrine is readily absorbed from the gastro-intestinal tract. It is resistant to metabolism by monoamine o Baca dokumen lengkap