FLUCOR DAY SOFT GELATIN CAPSULE

País: Malasia

Idioma: inglés

Fuente: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes activos:

PSEUDOEPHEDRINE HYDROCHLORIDE; Paracetamol; DEXTROMETHORPHAN HYDROBROMIDE

Disponible desde:

HOVID BERHAD

Designación común internacional (DCI):

PSEUDOEPHEDRINE HYDROCHLORIDE; Paracetamol; DEXTROMETHORPHAN HYDROBROMIDE

Unidades en paquete:

100Capsule Capsules; 8Capsule Capsules

Fabricado por:

HOVID BERHAD

Ficha técnica

026
FLUCOR DAY
WIFLUxx-0 (MY)
DESCRIPTION
Oblong, pink soft gelatin capsule filled with transparent
liquid.
COMPOSITION
Each soft gelatin capsule contains:
Paracetamol
250.0 mg
Dextromethorphan HBr
10.0 mg
Pseudoephedrine HC
_l_
30.0 mg
ACTIONS AND PHARMACOLOGY
Paracetamol, as an analgesic, may act predominantly by
inhibiting prostaglandin synthesis in the central nervous
system (CNS) and, to a lesser extent, through a peripheral
action by blocking pain-impulse generation. The peripheral
action
may
also
be
due
to
inhibition
of
prostaglandin
synthesis or to inhibition of the synthesis or actions of other
substances that sensitize pain receptors to mechanical or
chemical
stimulation.
Paracetamol
probably
produces
antipyresis
by
acting
centrally
on
the
hypothalamic
heat-regulating center to produce peripheral vasodilation
resulting in increased blood flow through the skin, sweating,
and heat loss. The central action probably involves inhibition
of prostaglandin synthesis in the hypothalamus.
Pseudoephedrine acts on alpha-adrenergic receptors in the
mucosa of the respiratory tract, producing vasoconstriction.
The medication shrinks swollen nasal mucous membranes;
reduces hyperemia, edema, and nasal congestion; and
increases nasal airway patency. Also drainage of sinus
secretions may be increased and obstructed Eustachian
ostia may be opened.
Dextromethorphan suppresses the cough reflex by a direct
action on the cough center in the medulla of the brain.
PHARMACOKINETICS
Paracetamol is readily absorbed from the gastrointestinal
tract with peak plasma concentrations occurring about 10 to
60 minutes after oral administration and is distributed into
most body tissues. The elimination half-life of paracetamol
varies
from
about
1
to
3
hours.
It
is
metabolized
predominantly in the liver and excreted in the urine mainly as
the glucoronide and sulphate conjugates, less than 5% is
excreted as unchanged paracetamol.
Pseudoephedrine is readily absorbed from the gastro-intestinal
tract. It is resistant to metabolism by monoamine o