FEPRIL SYRUP 120MG5ML

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Paracetamol

Boleh didapati daripada:

IDAMAN PHARMA MANUFACTURING SDN BHD

INN (Nama Antarabangsa):

Paracetamol

Unit dalam pakej:

120 ml; 60 ml; 120 ml; 60 ml; 60 ml; 120 ml; 60 ml; 120 ml

Dikeluarkan oleh:

IDAMAN PHARMA MANUFACTURING SDN BHD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
FEPRIL SYRUP 120MG/5ML
Paracetamol (120mg /5mL)
1
WHAT IS IN THIS LEAFLET
1.
What Fepril Syrup 120mg/5ml is used
for
2.
How Fepril Syrup 120mg/5ml works
3.
Before
you
use
Fepril
Syrup
120mg/5ml
4.
How to use Fepril Syrup 120mg/5ml
5.
While you are using it
6.
Side Effects
7.
Storage and Disposal of Fepril Syrup
120mg/5ml
8.
Product Description
9.
Product
Registration
Holder
&
Manufacturer
10.
Date of Revision
WHAT FEPRIL SYRUP 120MG/5ML IS USED
FOR
Fepril Syrup 120mg/5ml is used for relief
of
fever
and
mild
to
moderate
pain
associated with conditions such as aches
due to headaches, colds and flu symptoms,
teething pain, toothaches, earache and post
vaccination reactions.
HOW
FEPRIL
SYRUP
120MG/5ML
WORKS
Fepril Syrup 120mg/5ml has pain relief
and
anti-fever
properties.
It
works
by
blocking the pain impulse generation and
increasing
the
pain
threshold.
It
also increases the blood flow across the
skin, heat loss and sweating to reduce pain.
BEFORE YOU USE FEPRIL SYRUP 120MG/5ML
_-When you must not use it _
You
must
not
take
this
medicine
and
should talk to your doctor or pharmacist if:
•
You
are
allergic
to
Paracetamol
or
Acetaminophen or any other ingredients
found in the syrup.
•
You are not sure whether you should start
taking this medicine
_Pregnancy and breast-feeding _
Do not use if you are pregnant, thinking of
becoming pregnant, or breast feeding. Ask
your
doctor
or
pharmacist
for
advice
before taking any medicine.
_-Before you start to use it _
Tell your doctor or pharmacist if you have
any of the conditions mentioned below:
•
If you are intolerant of aspirin.
•
If
you
have
ever
had
a
serious
skin
reaction because paracetamol may cause
serious skin reactions which can be fatal.
_-Taking other medicines _
Please inform your doctor or pharmacist if
you are taking any or have recently taken
any
other
medicine
even
those
not
prescribed
which
you
obtained
from
a
pharmacy,
medical
hall
or
any
other
source.
The effects of some medicines may be
affected if

Ciri produk

FEPRIL SYRUP 120MG/5ML
DESCRIPTION
A pinkish red clear syrup with a raspberry flavor.
COMPOSITION
Each 5 ml contains Paracetamol :120mg
_Preservatives:_
Methyl Paraben :6 mg
Propyl Paraben :1 mg
PHARMACODYNAMICS
_Pharmacotherapeutic _
_group_:
Other Analgesics
and Antipyretics;
anilides
_ATC Code_: N02BE01
Paracetamol is a centrally acting analgesic and antipyretic with
minimal anti-inflammatory properties.
Analgesic
The mechanism of analgesic action has not been fully determined.
Paracetamol
may
act
predominantly
by
inhibiting
prostaglandin
synthesis
in
the
central
nervous
system
(CNS)
especially
cyclooxygenase (COX)-2 and, to a lesser extent, through a peripheral
action by blocking pain impulse generation. The peripheral action
may be due to inhibition of prostaglandin synthesis or to inhibition
of
the synthesis or actions of other substances that sensitize pain
receptors to mechanical or chemical stimulation.
Antipyretic
Paracetamol probably produces antipyresis by acting centrally on the
hypothalamic
heat-regulating
center
to
produce
peripheral
vasodilation resulting in increased blood flow through the skin,
sweating,
and
heat
loss.
The
central
action
probably
involves
inhibition of prostaglandin synthesis in the hypothalamus.
PHARMACOKINETICS
Paracetamol is rapidly and almost completely absorbed from the
gastrointestinal tract following oral administration. Approximately 90
to 95% of a dose is metabolized in the liver, primarily by conjugation
with glucuronic acid, sulfuric acid and cysteine. An intermediate
metabolite, which may accumulate in overdosage after the primary
metabolic pathways become saturated, is hepatotoxic and possibly
nephrotoxic. The half-life of paracetamol, 1 to 4 hours following oral
administrations, does not change with renal failure but may be
prolonged in acute overdosage, in some forms of hepatic disease, in
the elderly, and in the neonate. However, it may be somewhat
shortened in children. The time for paracetamol to reach its peak
concentration is 0.5 to 2 hours and time needed to