Emend IV

Country: Australia

Bahasa: Inggeris

Sumber: Department of Health (Therapeutic Goods Administration)

Bahan aktif:

Fosaprepitant dimeglumine

Boleh didapati daripada:

Merck Sharp & Dohme Australia Pty Ltd

Kelas:

Medicine Listed (Export Only)

Risalah maklumat

EMEND
®
 I.V.

_Fosaprepitant_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about EMEND I.V.. It does
not contain all the available
information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using EMEND I.V.
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
USING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT EMEND I.V. IS
USED FOR
CHEMOTHERAPY INDUCED NAUSEA
AND VOMITING
EMEND I.V., in combination with
other medicines, is used to prevent
•
nausea (feeling sick) and
vomiting associated with cancer
chemotherapy.
EMEND I.V. belongs to a group of
medicines called neurokinin 1 (NK1)
receptor antagonists. It works by
blocking the actions of substances in
your brain, called substance P
neurokinins, that cause nausea and
vomiting.
Your doctor may have prescribed
EMEND I.V. for another reason. Ask
your doctor if you have any questions
about why EMEND I.V. has been
prescribed for you.
The safety and effectiveness of
EMEND I.V. in children and
teenagers under the age of 18 years
have not been established.
EMEND I.V. is not addictive.
BEFORE YOU ARE GIVEN
EMEND I.V.
_WHEN YOU MUST NOT BE GIVEN_
_IT_
DO NOT USE EMEND I.V. IF YOU
HAVE AN ALLERGY TO EMEND I.V.,
APREPITANT OR ANY OF THE
INGREDIENTS LISTED AT THE END OF THIS
LEAFLET.
DO NOT USE EMEND I.V. IF YOU ARE
TAKING:
•
cisapride, used to treat stomach
reflux
•
pimozide, used to treat psychotic
conditions
•
terfenadine (Teldane#) and
astemizole (Hismanal#),
antihistamines used for allergic
conditions, including hayfever
 # not available in Australia
•
St John's Wort - a herb used to
treat depression
Using EMEND I.V. with these
medicines may cause serious or life-
threatening reactions.
DO NOT USE EMEND I.V. IF YOU ARE
BREAST-FEEDING OR PLAN TO BREAST-
FEED.
It is not known if EMEND I.V.
p

Ciri produk

PRODUCT INFORMATION 

EMEND

 I.V.

(
fosaprepitant dimeglumine, MSD
) 

DESCRIPTION 

Fosaprepitant dimeglumine is a prodrug
of aprepitant and is chemically described as 
1-Deoxy-1-(methylamino)-D-glucitol [3-[[(2_R_,3_S_)-2-[(1_R_)-1-[3,5-  
bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-
dihydro-5-oxo-1_H_-1,2,4-triazol-1-yl]phosphonate (2:1) (salt).  

Its empirical formula is C
23
H
22
F
7
N
4
O
6
P 

 2(C
7
H
17
NO
5
)

and its structural formula is:   
_ _
_ _
N
O
O
CF
3
CF
3
F
N
NH
O
CH
3
O
P
N
HO
HO
H
3
C
H
N
OH
OH
OH
OH
OH
2
.

Fosaprepitant  dimeglumine  is  a  white  to  off-white  amorphous  powder  with  a 
molecular weight of 1004.83. It is freely soluble in water.  The CAS No. is 265121-04-
8. 

Aprepitant is a structurally novel substance P neurokinin 1 (NK
1
) receptor antagonist, 
chemically  described  as  5-[[(2_R_,3_S_)-2-[(1_R_)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-
3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3_H_-1,2,4-triazol-3-one. 
Its empirical formula is

C
23
H
21
F
7
N
4
O
3
, and its structural formula is: 

Aprepitant is a white to off-white crystalline solid, with a molecular weight of 534.43.  
It  is  practically  insoluble  in  water.    Aprepitant  is  sparingly  soluble  in  ethanol  and 
isopropyl acetate and slightly soluble in acetonitrile. 

EMEND  I.V.  is  available  as  a  150  mg  and  115  mg  I.V.  for  infusion.  Each  vial  of 
EMEND I.V. 115 mg for intravenous administration contains 188 mg of fosaprepitant 
dimeglumine  equivalent  to  115mg  of  Fosaprepitant  free  acid.    Each  vial  of  EMEND 
I.V.  150  mg  for  intravenous  administration  contains  245.3  mg  of  fosaprepitant 
dimeglumine equivalent to 150 mg fosaprepitant free ac