CUINE Oral powder 1500mg

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Glucosamine Sulfate Sodium Chloride

Boleh didapati daripada:

DKSH MALAYSIA SDN BHD

INN (Nama Antarabangsa):

Glucosamine Sulfate Sodium Chloride

Unit dalam pakej:

4gm mcg/mL

Dikeluarkan oleh:

PYMEPHARCO

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET _
_(RIMUP) _
CUINE ORAL POWDER
Glucosamine sulfate (1500 mg)
1
WHAT IS IN THIS LEAFLET
1.
What CUINE Oral powder is
used for
2.
How it works
3.
Before you use CUINE Oral
powder
4.
How to use CUINE Oral
powder
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of
CUINE Oral powder
8.
Product Description
9.
Manufacturer and Product
registration Holder
10.
Date of revision
WHAT CUINE ORAL POWDER IS USED
FOR
As additional therapy for
osteoarthritis (inflammation of joints
due to cartilage degeneration).
HOW CUINE ORAL POWDER WORKS
Glucosamine is a natural substance,
involved in the building of cartilage
tissue in the body; glucosamine is
also present in tendons and ligaments.
Glucosamine acts to improve the
viscosity of fluid that surrounds joints
by increasing fluid production,
thereby providing lubricant activity.
BEFORE YOU USE CUINE ORAL
POWDER
_- When you must not use it _
-
Hypersensitivity to glucosamine or
to any of the ingredients.
-
As the active ingredient is obtained
from seafood (shellfish), the product
should not be given to people who are
allergic to shellfish.
-
Children: Safety and effectiveness
have not established in children.
Therefore children should avoid using
glucosamine.
Ask your doctor or pharmacist if you
are not sure.
_-Before you start to use it _
Tell your doctor about all your
medical conditions, including if you:
-
are breast feeding a baby; pregnant, or
trying to become pregnant soon.
Usage during the first three months of
pregnancy must be avoided.
-
are phenylketonuric.
-
have severe liver or kidney
insufficiency.
- have presence of other joint
conditions/diseases.
_-Taking other medicines _
Make sure your doctor knows what
other medicines you are taking,
including those that you have bought
yourself, especially medicines for:
-
diabetes such as acarbose, glipizide,
metformin, rosiglitazone, etc;
-
medicines for cancer such as
doxorubicin, etoposide and
teniposide;
-
medicines for blood thinning
such as warfarin.
Glucosamine su

Ciri produk

NAME AND STRENGTH OF ACTIVE SUBSTANCE
Glucosamine sulfate sodium chloride 1884.15 equivalent to 1500 mg
glucosamine sulfate
PRODUCT DESCRIPTION
CUINE Oral powder 1500 mg appears as white, loose and dry, uniform in
colour powder. The reconstituted solution
appears as clear, white to colourless, lemon flavor solution.
PHARMACODYNAMIC
Glucosamine is a natural substance found in chitin, mucoproteins, and
mucopolysaccharides. It is involved in the
manufacture of glycosaminoglycan, which forms cartilage tissue in the
body; glucosamine is also present in tendons
and ligaments. Glucosamine must be synthesised by the body but the
ability to do this declines with age. Glucosamine
and its salts have therefore been advocated in the treatment of
rheumatic disorders including osteroarthritis.
Glucosamine also acts to improve the viscosity of synovial fluid by
increasing synovial fluid production, thereby
providing lubricant activity.
PHARMACOKINETIC
_Absorption_
: After oral administration, bioavailability is low due to first-pass
hepatic metabolism ~ 26%. The
gastrointestinal absorption is close to 90%.
_Distribution_
: Glucosamine is not protein-bound, but rather incorporates into
plasma proteins (primarily globulins).
Volume of distribution is about 2.5 litres
_Metabolism_
: Liver, extensive. The first-pass effect in the liver in which more
than 70% of glucosamine is metabolized.
_Elimination_
: Renal excretion, 10%. Feces, 11%. Part of a dose glucosamine sulfate
is eliminated as carbon dioxide via
expired air.
INDICATIONS
As adjuvant therapy for osteoarthritis.
RECOMMENDED DOSAGE
Adults: 1 sachet (dissolved in a glass of water) once daily. The
treatment of osteoarthritis should be repeated every other
6 months or less (according to medical prescription)
Children: Safety and effectiveness have not established in children.
MODE OF ADMINISTRATION
Oral
CONTRA-INDICATIONS
Hypersensitivity to glucosamine or to any of the excipients.
As the active ingredient is obtained from seafood ( shellfish), the
product should not be given t