AVEFLON TABLET

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

Hesperidin; Diosmin

Boleh didapati daripada:

APEX PHARMACY MARKETING SDN. BHD.

INN (Nama Antarabangsa):

Hesperidin; Diosmin

Unit dalam pakej:

3 x 10 Tablets

Dikeluarkan oleh:

XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD

Risalah maklumat

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
AVEFLON TABLET
(Micronized Purified Flavonoid Fraction 500mg- Diosmin 450mg;
Hesperidin 50mg)
1
WHAT IS IN THIS LEAFLET:
1.
What is Aveflon used for
2.
How Aveflon works
3.
Before you use Aveflon
4.
How to use Aveflon
5.
While you are using Aveflon
6.
Side effects
7.
Storage and disposal of Aveflon
8.
Product description
9.
Manufacturer and Product Registration
Holder
10.
Date of revision
WHAT IS AVEFLON USED FOR
For the treatment of:
-Symptoms related to venolymphatic
insufficiency (a condition where the flow
of blood through the veins is inadequate,
causing blood to pool in the legs), such as
heavy legs, pain, early morning restless
leg.
- Functional symptoms related to acute
hemorrhoidal attack. Hemorrhoids are
vascular structures in the anal canal. In
normal condition, they are cushions that
help with stool control. They become a
disease when swollen or inflamed.
HOW AVEFLON WORKS
Micronized
purified
flavonoid
fraction
containing
Diosmin
and
Hesperidin.
Diosmin is synthesized from Hesperidin.
Hesperidin is a flavonoid found in citrus
fruits.
Aveflon is used to treat and protect blood
vessel by reducing the distention of blood
vessel and the slowdown in the flow of
blood. It also increases the permeability and
strengthens the resistance of capillary (fine
branching of blood vessels).
BEFORE YOU USE AVEFLON
_When you must not to use it _
Do not use Aveflon if:
•
You
are
allergic
to
Diosmin
or
Hesperidin.
_ _
_ _
_Before you start to use it _
Tell your doctor or pharmacist if you:
•
are pregnant or plan to pregnant
_ _
•
are breast-feeding.
_ _
•
have hemorrhoids.
_ _
_ _
_Taking other medicines _
•
Tell your doctor or pharmacist if you
are taking or have recently taken any
other
medicines.
This
includes
any
medicines
which
you
have
bought
without a prescription.
HOW TO USE AVEFLON
_How much to use _
Usual dose
2 tablets daily. 1 tablet at mid-day and 1
tablet in the evening at meal times.
Acute Hemorrhoidal Attack
First 4 days- 6 tablets daily
Subsequ

Ciri produk

Important Information. Please read carefully.
Aveflon
Tablet 500 mg
COMPOSITION
Each film-coated tablet contains Micronized Purified Flavonoid
Fraction 500mg.
- Diosmin 90% (450mg)
- Hesperidin 10% (50mg)
PHARMACODYNAMICS
Micronized purified flavonoid fraction is a venotonic and vascular
protector. It exerts an action on the vascular return system by
reducing the venous distensibility and stasis (at the venous level)
and
normalises
capillary
permeability
and
increases
capillary
resistance (at the microcirculatory level).
PHARMACOKINETICS
Diosmin
is
synthesized
from
Hesperidin.
Diosmin
is
highly
metabolized and the elimination half-life is 11 hours. The
excretion of
Diosmin
is
mainly
faecal,
and
about
14%
of
the
dose
administered is excreted in the urine.
INDICATIONS
Aveflon is used for the treatment of:
• Symptoms related to venolymphatic insufficiency, such as heavy
legs, pain, early morning restless leg.
• Functional symptoms related to acute hemorrhoidal attack.
DOSAGE AND ADMINISTRATION
For oral use only.
Usual Dosage
2 tablets daily: 1 tablet at mid-day and 1 tablet in the evening at
meal times.
Acute Hemorrhoidal Attack
First 4 days- 6 tablets daily
Subsequent 3 days- 4 tablets daily
CONTRAINDICATIONS
C o n t r a i n d i c a t e d
i n
p a t i e n t s
w i t h
k n o w n
h y p e r s e n s i t i v i t y
to
micronized purified flavonoid fraction.
WARNINGS AND PRECAUTIONS
Acute Hemorrhoidal Attack
The administration of this product is not substituting the specific
treatment
of
other
anal
disorders.
The
treatment
must
be
short-term. If the symptoms do not disappear rapidly, proctological
examination should be performed and the treatment should be
reviewed.
DRUG INTERACTIONS
No clinically significant interactions is available with the use of
micronized purified flavonoid fraction.
PREGNANCY AND LACTATION
Pregnancy
Experimental studies available have not shown any teratogenic
effect in animals. No harmful effects have been reported to date in
humans.
Lactation
In
the
absence
of
studies
concerning
excretion
into