Country: Մալայզիա
language: անգլերեն
source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Hesperidin; Diosmin
APEX PHARMACY MARKETING SDN. BHD.
Hesperidin; Diosmin
3 x 10 Tablets
XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ AVEFLON TABLET (Micronized Purified Flavonoid Fraction 500mg- Diosmin 450mg; Hesperidin 50mg) 1 WHAT IS IN THIS LEAFLET: 1. What is Aveflon used for 2. How Aveflon works 3. Before you use Aveflon 4. How to use Aveflon 5. While you are using Aveflon 6. Side effects 7. Storage and disposal of Aveflon 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT IS AVEFLON USED FOR For the treatment of: -Symptoms related to venolymphatic insufficiency (a condition where the flow of blood through the veins is inadequate, causing blood to pool in the legs), such as heavy legs, pain, early morning restless leg. - Functional symptoms related to acute hemorrhoidal attack. Hemorrhoids are vascular structures in the anal canal. In normal condition, they are cushions that help with stool control. They become a disease when swollen or inflamed. HOW AVEFLON WORKS Micronized purified flavonoid fraction containing Diosmin and Hesperidin. Diosmin is synthesized from Hesperidin. Hesperidin is a flavonoid found in citrus fruits. Aveflon is used to treat and protect blood vessel by reducing the distention of blood vessel and the slowdown in the flow of blood. It also increases the permeability and strengthens the resistance of capillary (fine branching of blood vessels). BEFORE YOU USE AVEFLON _When you must not to use it _ Do not use Aveflon if: • You are allergic to Diosmin or Hesperidin. _ _ _ _ _Before you start to use it _ Tell your doctor or pharmacist if you: • are pregnant or plan to pregnant _ _ • are breast-feeding. _ _ • have hemorrhoids. _ _ _ _ _Taking other medicines _ • Tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes any medicines which you have bought without a prescription. HOW TO USE AVEFLON _How much to use _ Usual dose 2 tablets daily. 1 tablet at mid-day and 1 tablet in the evening at meal times. Acute Hemorrhoidal Attack First 4 days- 6 tablets daily Subsequ read_full_document
Important Information. Please read carefully. Aveflon Tablet 500 mg COMPOSITION Each film-coated tablet contains Micronized Purified Flavonoid Fraction 500mg. - Diosmin 90% (450mg) - Hesperidin 10% (50mg) PHARMACODYNAMICS Micronized purified flavonoid fraction is a venotonic and vascular protector. It exerts an action on the vascular return system by reducing the venous distensibility and stasis (at the venous level) and normalises capillary permeability and increases capillary resistance (at the microcirculatory level). PHARMACOKINETICS Diosmin is synthesized from Hesperidin. Diosmin is highly metabolized and the elimination half-life is 11 hours. The excretion of Diosmin is mainly faecal, and about 14% of the dose administered is excreted in the urine. INDICATIONS Aveflon is used for the treatment of: • Symptoms related to venolymphatic insufficiency, such as heavy legs, pain, early morning restless leg. • Functional symptoms related to acute hemorrhoidal attack. DOSAGE AND ADMINISTRATION For oral use only. Usual Dosage 2 tablets daily: 1 tablet at mid-day and 1 tablet in the evening at meal times. Acute Hemorrhoidal Attack First 4 days- 6 tablets daily Subsequent 3 days- 4 tablets daily CONTRAINDICATIONS C o n t r a i n d i c a t e d i n p a t i e n t s w i t h k n o w n h y p e r s e n s i t i v i t y to micronized purified flavonoid fraction. WARNINGS AND PRECAUTIONS Acute Hemorrhoidal Attack The administration of this product is not substituting the specific treatment of other anal disorders. The treatment must be short-term. If the symptoms do not disappear rapidly, proctological examination should be performed and the treatment should be reviewed. DRUG INTERACTIONS No clinically significant interactions is available with the use of micronized purified flavonoid fraction. PREGNANCY AND LACTATION Pregnancy Experimental studies available have not shown any teratogenic effect in animals. No harmful effects have been reported to date in humans. Lactation In the absence of studies concerning excretion into read_full_document