Country: Malaysia
Bahasa: Inggeris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ACYCLOVIR
DKSH MALAYSIA SDN BHD
ACYCLOVIR
35Tablet Tablets
STADA Arzneimittel AG
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ ACYCLOVIR 400 STADA Acyclovir 400 mg 1 WHAT IS IN THIS LEAFLET 1. What Acyclovir 400 STADA is used for 2. How Acyclovir 400 STADA works 3. Before you take Acyclovir 400 STADA 4. How to take Acyclovir 400 STADA 5. While you are using Acyclovir 400 STADA 6. Side effects 7. Storage and Disposal of Acyclovir 400 STADA 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT ACYCLOVIR 400 STADA IS USED FOR Acyclovir 400 STADA is a medicine for the treatment of viral infections (antiviral agent). Acyclovir is used for Shingles (herpes zoster) and prevention of severe cases simplex infection in severely immunocompromised adult patients exposed to an elevated risk of infection, for example following organ transplants. HOW ACYCLOVIR 400 STADA WORKS Acyclovir is an antiviral medicine, which acts on infected cells by stopping the virus growing. BEFORE YOU USE ACYCLOVIR 400 STAD _When you must not take it _ - If you are allergic (hypersensitive) to medications containing acyclovir or valacyclovir, or any of the other ingredients of Acyclovir 400 STADA. - If your kidney function is impaired or your urinary output is reduced to less than 100ml of urine per 24 hours, you should not use Acyclovir 400 STADA for prevention because no data are available on the use of Acyclovir 400 STADA in these conditions. - Acyclovir has been detected in breast milk following administration of acyclovir products. Breast-feeding is therefore discouraged while taking Acyclovir 400 Stada. _Before you start to take it _ - Please discuss with your doctor or pharmacist before taking Acyclovir 400 Stada. _Taking other medicine _ - Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Probenecid (uricosuric drug for gout) reduces acyclovir excretion via the kidneys, which may increase acyclovir persistence in the body. HOW TO TAKE ACYCLOVIR 400 STADA _How much to take Baca dokumen lengkap
Prescribing Information STADA Arzneimittel AG, D-61118 Bad Vilbel, Germany Dear patient, Please be sure to carefully read this Insert because it contains important information on how to use this medication effectively and safely. If you have any questions or concerns, please do not hesitate to ask your doctor or pharmacist. Acyclovir 400 Stada ® Product Description Round, White, biconvex tablets. Imprint: VS2 Composition Each tablet contains: Pharmacologically active ingredient: Acyclovir, 400mg Other ingredients: Microcrystalline cellulose, copolyvidon, magnesium stearate, sodium starch glycolate, colloidal anhydrous silica Presentation and contents Original package of 35 tablets Acyclovir 400 Stada ® is an antiviral drug Pharmacodynamics Mode of Action Acyclovir is a guanine derivative whose activity is essentially confined to viral thymidine kinase-producing human pathogenic herpes viruses, i.e. herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella-zoster virus (VSV). Acyclovir is not pharmacologically active until it has been converted by viral thymidine kinase inside virally infected cells along the following pathway: Phosphorylation of acyclovir (the substrate) to acyclovir monophosphate is faster by viral thymidine kinase than by host cell thymidine kinase. This relative selectivity minimizes the toxicity of acyclovir to host cells. Normal cellular nucleotidyl phosphotransferases then catalyse the sequential conversion of acyclovir monophosphate to acyclovir triphosphate. Acyclovir triphosphate (the active form of the drug) selectively inhibits viral DNA polymerase and is incorporated into viral DNA. Acyclovir triphosphate competitively displaces deoxyguanosine triphosphate nom DNA polymerases. Acyclovir triphosphate has higher affinity for HSV-encoded DNA polymerase than cellular DNA polymerase (10 to 20 times greater). It acts as a substrate for HSV-encoded DNA polymerase and, cleaving off diphosphate is incorporated into viral DNA. However, as acyclovir lacks a 3’-hydroxyl group, nucle Baca dokumen lengkap