ACYCLOVIR 400 STADA

Maa: Malesia

Kieli: englanti

Lähde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiivinen ainesosa:

ACYCLOVIR

Saatavilla:

DKSH MALAYSIA SDN BHD

INN (Kansainvälinen yleisnimi):

ACYCLOVIR

Kpl paketissa:

35Tablet Tablets

Valmistaja:

STADA Arzneimittel AG

Pakkausseloste

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
ACYCLOVIR 400 STADA
Acyclovir 400 mg
1
WHAT IS IN THIS LEAFLET
1.
What Acyclovir 400 STADA is used
for
2.
How Acyclovir 400 STADA works
3.
Before
you
take
Acyclovir
400
STADA
4.
How to take Acyclovir 400 STADA
5.
While you are using Acyclovir 400
STADA
6.
Side effects
7.
Storage and Disposal of Acyclovir
400 STADA
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT ACYCLOVIR 400 STADA IS USED
FOR
Acyclovir 400 STADA is a medicine for
the treatment of viral infections (antiviral
agent). Acyclovir is used for Shingles
(herpes zoster) and prevention of severe
cases
simplex
infection
in
severely
immunocompromised
adult
patients
exposed to an elevated risk of infection,
for example following organ transplants.
HOW ACYCLOVIR 400 STADA WORKS
Acyclovir is an antiviral medicine, which
acts on infected cells by stopping the
virus growing.
BEFORE YOU USE ACYCLOVIR 400 STAD
_When you must not take it _
-
If
you
are
allergic
(hypersensitive)
to
medications
containing
acyclovir
or
valacyclovir, or any of the other
ingredients
of
Acyclovir
400
STADA.
-
If
your
kidney
function
is
impaired or your urinary output is
reduced
to
less
than
100ml
of
urine per 24 hours, you should not
use Acyclovir 400 STADA for
prevention because no data are
available on the use of Acyclovir
400 STADA in these conditions.
-
Acyclovir has been detected in
breast
milk
following
administration
of
acyclovir
products.
Breast-feeding
is
therefore
discouraged
while
taking Acyclovir 400 Stada.
_Before you start to take it _
-
Please discuss with your doctor
or
pharmacist
before
taking
Acyclovir 400 Stada.
_Taking other medicine _
-
Please
tell
your
doctor
or
pharmacist if you are taking or
have
recently
taken
any
other
medicines,
including
medicines
obtained
without
a
prescription.
Probenecid
(uricosuric
drug
for
gout) reduces acyclovir excretion
via
the
kidneys,
which
may
increase acyclovir persistence in
the body.
HOW TO TAKE ACYCLOVIR 400 STADA
_How much to take

Valmisteyhteenveto

Prescribing Information
STADA Arzneimittel AG, D-61118 Bad Vilbel, Germany
Dear patient,
Please be sure to carefully read this Insert because it contains
important information on how to use this medication
effectively and safely. If you have any questions or concerns, please
do not hesitate to ask your doctor or pharmacist.
Acyclovir 400 Stada
®
Product Description
Round, White, biconvex tablets. Imprint: VS2
Composition
Each tablet contains:
Pharmacologically active ingredient:
Acyclovir, 400mg
Other ingredients:
Microcrystalline cellulose, copolyvidon, magnesium stearate, sodium
starch glycolate, colloidal anhydrous silica
Presentation and contents
Original package of 35 tablets
Acyclovir 400 Stada
®
is an antiviral drug
Pharmacodynamics
Mode of Action
Acyclovir is a guanine derivative whose activity is essentially
confined to viral thymidine kinase-producing human
pathogenic herpes viruses, i.e. herpes simplex virus types 1 and 2
(HSV-1 and HSV-2), and varicella-zoster virus
(VSV). Acyclovir is not pharmacologically active until it has been
converted by viral thymidine kinase inside virally
infected cells along the following pathway:
Phosphorylation of acyclovir (the substrate) to acyclovir
monophosphate is faster by viral thymidine kinase than by
host cell thymidine kinase. This relative selectivity minimizes the
toxicity of acyclovir to host cells. Normal cellular
nucleotidyl phosphotransferases then catalyse the sequential
conversion of acyclovir monophosphate to acyclovir
triphosphate.
Acyclovir triphosphate (the active form of the drug) selectively
inhibits viral DNA polymerase and is incorporated
into viral DNA. Acyclovir triphosphate competitively displaces
deoxyguanosine triphosphate nom DNA
polymerases. Acyclovir triphosphate has higher affinity for
HSV-encoded DNA polymerase than cellular DNA
polymerase (10 to 20 times greater). It acts as a substrate for
HSV-encoded DNA polymerase and, cleaving off
diphosphate is incorporated into viral DNA. However, as acyclovir
lacks a 3’-hydroxyl group, nucle