妥泰膜衣錠２００毫克

Country: Taiwan

Bahasa: Cina

Sumber: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)

Bahan aktif:

TOPIRAMATE

Boleh didapati daripada:

嬌生股份有限公司 台北市中山區民生東路三段2號10樓及11樓 (30814854)

Kod ATC:

N03AX11

Borang farmaseutikal:

錠劑

Komposisi:

TOPIRAMATE (9200038300) MG

Unit dalam pakej:

塑膠瓶裝;;鋁箔盒裝

Kelas:

製　劑

Jenis preskripsi:

須由醫師處方使用

Dikeluarkan oleh:

CILAG AG. HOCHSTRASSE 201 CH-8200 SCHAFFHAUSEN SWITZERLAND CH

Kawasan terapeutik:

topiramate

Tanda-tanda terapeutik:

用於成人及兩歲以上兒童局部癲癇或併有LENNOX-GASTAUT症候群之癲癇及原發性全身性強直陣攣癲癇的輔助治療，用於PARTIAL ONSET SEIZURE病患之單一藥物治療、預防偏頭痛。

Ringkasan produk:

有效日期: 2029/06/07; 英文品名: TOPAMAX FILM-COATED TABLETS 200MG

Tarikh kebenaran:

1999-06-07

Risalah maklumat

®
TOPAMAX
® FILM-COATED TABLETS
200
200 mg
022510
®
TOPAMAX
® FILM-COATED TABLETS
200
200 mg
022510
AED
AED
TOPAMAX
Phenytoin
Carbamazepine CBZ
Valproic acid
Lamotrigine
Phenobarbital
Primidone
↔
**
↔
↔
↔
↔
↔
↓
48%
↓
40%
↔
↔
NS
NS
↔ 
=
< 15%
** =
 ↓ 
=
NS =
AED =
Digoxin
TOPAMAX
digoxin
AUC
12%
digoxin
TOPAMAX
digoxin
TOPAMAX
TOPAMAX
TOPAMAX
50
200 mg/day
EE
AUC
TOPAMAX
estrogen
Lithium
lithium
topiramate 200 mg/day
lithium
18% for AUC
lithium
topiramate 200 mg/day
lithium
topiramate
600 mg/day
26% for AUC
topiramate
lithium
Risperidone
topiramate
100
250
400 mg/day
risperidone
1
6 mg/day
steady-state AUC
250 mg/day
400 mg/day
16% 33%
risperidone
9-hydroxyrisperidone
9-hydroxyrisperidone
Risperidone
topiramate
Hydrochlorothiazide HCTZ
HCTZ 25 mg
24
Topiramate 96 mg
12
HCTZ
topiramate
topiramate
C
max
27% AUC
29%
HCTZ
topiramate
topiramate
HCTZ
topiramate
topiramate
HCTZ
HCTZ
topiramate
Metformin
metformin
metformin
topiramate
metformin
topiramate
metform
in
topiramate
metformin
C
max
AUC
0-12h
18%
25%
CL/F
20% Topiramate
metformin
t
max
Topiramate
metformin
metformin
topiramate
Metformin
topiramate
metformin
TOPAMAX
Pioglitazone
topiramate
pioglitazone
pioglitazone
AUC
τ
,ss
15% C
max,ss
hydroxy-
C
max,ss
AUC
τ
,ss
13%
16%
keto-
C
max,ss
AUC
τ
,ss
60%
TOPAMAX
pioglitazone
pioglitazone
TOPAMAX
Glyburide
glyburide 5 mg/day
topiramate 150 mg/day
Topiramate
glyburide
AUC
24
25%
4-trans-hydroxy-glyburide M1
3-cis-hydroxyglyburide
M2
13% 15% Topiramate
glyburide
topiramate
glyburide
glyburide
topiramate
TOPAMAX
TOPAMAX
Vitamin K-
topiramate
vitamin K-
酶
/
Prothrombin Time/International
Normalized Ratio, PT/INR
topiramate
vitamin K-
INR
topiramate
C
max
AUC
topiramate
topiramate
topiramate
a
Topiramate
a
Amitriptyline
↔
nortriptyline
C
max
AUC
20%
NS
Dihydroergotamine
↔
↔
Haloperidol
↔
AUC
31%
NS
Propranolol
↔
4-OH propranolol
TPM
50 mg q12h
C
max
17%
C
max
9%
16% AUC
9% 17%
40 mg
80 mg
propranolol q12h
Sumatriptan
↔
NS
Pizotifen
↔
↔
Diltiazem
Diltiazem
AUC
25%
DEA