Šalis: Kanada
kalba: anglų
Šaltinis: Health Canada
VITAMIN D3
JAMP PHARMA CORPORATION
A11CC05
COLECALCIFEROL
2000UNIT
CAPSULE
VITAMIN D3 2000UNIT
ORAL
100
Prescription
VITAMIN D
Active ingredient group (AIG) number: 0108524011; AHFS:
APPROVED
2020-09-14
1 PRESCRIBING INFORMATION PR VITAMIN D CHOLECALCIFEROL CAPSULES, MFR. STD. 2000 IU VITAMIN D PRODUCT PREPARED BY: Date of Preparation: September 14, 2020 JAMP Pharma Corporation 1310 rue Nobel Boucherville QC J4B 5H3 SUBMISSION CONTROL NUMBER: 240944 2 PRESCRIBING INFORMATION PR VITAMIN D Cholecalciferol Capsules, Mfr. Std. 2000 IU THERAPEUTIC CLASSIFICATION Vitamin D Product PHARMACOLOGY Vitamin D is a fat-soluble vitamin that helps regulate serum calcium and phosphorous concentrations by enhancing the efficiency of the small intestine to absorb these minerals from the diet. Vitamin D has two main forms: cholecalciferol (Vitamin D 3 ), and ergocalciferol (Vitamin D 2 ). In humans, cholecalciferol is synthesized in the skin from 7-dehydrocholesterol on exposure to ultraviolet radiation and obtained from the diet from fish liver oils and salt water fish. In the absence of adequate sunlight exposure, vitamin D 3 is an essential dietary nutrient. Cholecalciferol is a prohormone with several active metabolites that act as hormones. Vitamin D is metabolised by the liver to form 25-hydroxycholecalciferol (calcifediol), which is then converted in the kidneys to the active Vitamin D hormone, 1,25-dihydroxyvitamin D 3 (calcitriol). In its biologically active form vitamin D 3 stimulates intestinal calcium absorption, incorporation of calcium into the osteoid, and release of calcium from bone tissue. In the small intestine it promotes rapid and delayed calcium uptake. The passive and active transport of phosphate is also stimulated. In the kidney, it inhibits the excretion of calcium and phosphate by promoting tubular resorption. The production of parathyroid hormone (PTH) in the parathyroids is inhibited directly by the biologically active form of vitamin D 3 . PTH secretion is inhibited further by the increased calcium uptake in the small intestine under the influence of biologically active vitamin D 3 . PHARMACOKINETICS Vitamin D from nutritional sources and its analogues are readily absorbed from the small intestine in Perskaitykite visą dokumentą