Šalis: Malaizija
kalba: anglų
Šaltinis: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol
AV MANUFACTURING SDN.BHD
Paracetamol
10 Tablet Tablets; 200 Tablet Tablets; 20 Tablet Tablets
AV MANUFACTURING SDN.BHD
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ AVADOL ® TABLET 500MG Paracetamol (500mg) 1 WHAT IS IN THIS LEAFLET 1. What is Avadol used for 2. How Avadol works 3. Before you take Avadol 4. How to use Avadol 5. While you are using Avadol 6. Side effects 7. Storage and disposal 8. Product description 9. Manufacturer & Product registration holder 10. Date of revision 1. WHAT IS AVADOL USED FOR Avadol helps to relieve fever, mild to moderate pain including: headache, migraine, backache, musculoskeletal pain, myalgia, dysmenorrhea (period pain), pain of osteoarthritis, toothache, and the discomfort from colds, influenza and sore throats. 2. HOW AVADOL WORKS Avadol contains the active ingredient paracetamol which is a painkiller and also reduces your temperature when you have a fever. It is absorbed fast by the body which means it can take action in a short time. 3. BEFORE YOU USE AVADOL _-When you must not use it_ If you have ever had allergic reaction to paracetamol or any of the other ingredients in this product. If you are taking any other medicines containing paracetamol. If you had severe and active liver problem. _-Before you start to use it_ Check with your doctor If you suffer from liver or kidney problems, including alcoholic liver disease. If you suffer from mild arthritis and need to take painkillers every day. _-Taking other medicines_ Please talk to your doctor or pharmacist, if you are taking any of the medicines below: blood thinning medicines (anticoagulants e.g. warfarin) pain relievers on a daily basis If you have recently taken any other medicines, including medicines obtained without prescription. _Pregnancy and breast-feeding _ Use in pregnancy: Considered to be the painkiller of choice in pregnant patients. Although it crosses placenta, paracetamol is considered to be safe in normal therapeutic doses for short- term use in minor pain or fever in pregnancy. Use in breastfeeding: Paracetamol taken by the mother is excreted into the breast milk, how Perskaitykite visą dokumentą
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S) Paracetamol 500mg PRODUCT DESCRIPTION Avadol tablet is a white to off white, round, film-coated tablet with 500 debossed on one side and plain on the other side. PHARMACODYNAMICS Paracetamol is a centrally acting analgesic and antipyretic with minimal anti-inflammatory properties. Analgesic The mechanism of analgesic action has not been fully determined. Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (specifically cyclooxygenase (COX)-2) and, to a lesser extent, through a peripheral action by blocking pain- impulse generation. The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation Antipyretic Paracetamol act centrally on the hypothalamic heat-regulating center to produce peripheral vasodilatation resulting in increased blood flow through the skin, sweating and heat loss. Paracetamol reduces fever by inhibiting the formulation and release of prostaglandins in the CNS and by inhibiting endogenous pyrogens at the hypothalamic thermoregulator center PHARMACOKINETICS Following oral administration paracetamol is rapidly absorbed. Paracetamol absorption takes place mainly in the small intestine and therefore the rate of absorption is depending on the rate of gastric emptying. It has been shown that drugs which delay gastric emptying also delay the absorption of paracetamol whereas metoclopramide (a drug which increases the rate of gastric emptying) accelerates absorption of the analgesic through the total amount absorbed doses not increase. The presence of food in the stomach has also been reported to reduce the rate of absorption of paracetamol. Alterations in gastric pH have no appreciable effect on paracetamol absorption. During absorption, the amount of paracetamol which is inactivated is negligible and it has been shown that paracetamol does not affect gastric mucosa Perskaitykite visą dokumentą