Avadol tablet 500 mg

Ország: Malajzia

Nyelv: angol

Forrás: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktív összetevők:

Paracetamol

Beszerezhető a:

AV MANUFACTURING SDN.BHD

INN (nemzetközi neve):

Paracetamol

db csomag:

10 Tablet Tablets; 200 Tablet Tablets; 20 Tablet Tablets

Gyártó:

AV MANUFACTURING SDN.BHD

Betegtájékoztató

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
AVADOL
® TABLET 500MG
Paracetamol (500mg)
1
WHAT IS IN THIS LEAFLET
1.
What is Avadol used for
2.
How Avadol works
3.
Before you take Avadol
4.
How to use Avadol
5.
While you are using Avadol
6.
Side effects
7.
Storage and disposal
8.
Product description
9.
Manufacturer & Product
registration holder
10.
Date of revision
1.
WHAT IS AVADOL USED FOR
Avadol helps to relieve fever, mild to
moderate pain including: headache,
migraine, backache, musculoskeletal
pain, myalgia, dysmenorrhea (period
pain), pain of osteoarthritis, toothache,
and the discomfort from colds, influenza
and sore throats.
2.
HOW AVADOL WORKS
Avadol contains the active ingredient
paracetamol which is a painkiller and
also reduces your temperature when you
have a fever. It is absorbed fast by the
body which means it can take action in
a short time.
3.
BEFORE YOU USE AVADOL
_-When you must not use it_

If you have ever had allergic reaction
to paracetamol or any of the other
ingredients in this product.

If you are taking any other
medicines containing paracetamol.

If you had severe and active liver
problem.
_-Before you start to use it_
Check with your doctor

If you suffer from liver or kidney
problems, including alcoholic liver
disease.

If you suffer from mild arthritis and
need to take painkillers every day.
_-Taking other medicines_
Please talk to your doctor or
pharmacist, if you are taking any of the
medicines below:

blood thinning medicines
(anticoagulants e.g. warfarin)

pain relievers on a daily basis

If you have recently taken any other
medicines, including medicines
obtained without prescription.
_Pregnancy and breast-feeding _
Use in pregnancy:

Considered to be the painkiller
of choice in pregnant patients.

Although it crosses placenta,
paracetamol is considered to be safe in
normal therapeutic doses for short-
term use in minor pain or fever in
pregnancy.
Use in breastfeeding:

Paracetamol taken by the mother is
excreted into the breast milk, how

Termékjellemzők

NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
Paracetamol 500mg
PRODUCT DESCRIPTION
Avadol tablet is a white to off white, round, film-coated tablet with
500 debossed on one side and plain on the other side.
PHARMACODYNAMICS
Paracetamol is a centrally acting analgesic and antipyretic with
minimal anti-inflammatory properties.
Analgesic
The mechanism of analgesic action has not been fully determined.
Paracetamol may act predominantly by inhibiting
prostaglandin synthesis in the central nervous system (specifically
cyclooxygenase (COX)-2) and, to a lesser extent, through a
peripheral action by blocking pain- impulse generation.
The peripheral action may also be due to inhibition of prostaglandin
synthesis or to inhibition of the synthesis or actions of
other substances that sensitize pain receptors to mechanical or
chemical stimulation
Antipyretic
Paracetamol
act centrally on
the hypothalamic
heat-regulating center to
produce
peripheral vasodilatation resulting in
increased blood flow through the skin, sweating and heat loss.
Paracetamol reduces fever by inhibiting the formulation and
release of prostaglandins in the CNS and by inhibiting endogenous
pyrogens at the hypothalamic thermoregulator center
PHARMACOKINETICS
Following oral administration paracetamol is rapidly absorbed.
Paracetamol absorption takes place mainly in the small intestine and
therefore the rate of absorption is depending on the rate
of gastric emptying. It has been shown that drugs which delay gastric
emptying also delay the absorption of paracetamol
whereas metoclopramide (a drug which increases the rate of gastric
emptying) accelerates absorption of the analgesic through
the total amount absorbed doses not increase.
The presence of food in the stomach has also been reported to reduce
the rate of absorption of paracetamol. Alterations in
gastric pH have no appreciable effect on paracetamol absorption.
During absorption, the amount of paracetamol which is
inactivated is negligible and it has been shown that paracetamol does
not affect
gastric mucosa