Šalis: Australija
kalba: anglų
Šaltinis: Department of Health (Therapeutic Goods Administration)
Anastrozole
Synthon Au Pty Ltd
Medicine Registered
ANASTROZOLE-SYNTHON CMI FEBRUARY 2011 Page 1 of 6 ANASTROZOLE-SYNTHON Anastrozole CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some of the common questions people ask about ANASTROZOLE- SYNTHON. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor will have weighed the risks of you taking it against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT ANASTROZOLE-SYNTHON IS USED FOR ANASTROZOLE-SYNTHON is used to treat breast cancer in women who no longer have their menstrual periods either naturally, due to their age or after surgery, radiotherapy or chemotherapy. It is a non-steroidal aromatase inhibitor, which reduces the amount of oestrogen (female sex hormone) made by the body. In some types of breast cancer, oestrogen can help the cancer cells grow. By blocking oestrogen, ANASTROZOLE-SYNTHON may slow or stop the growth of cancer. FOLLOW ALL DIRECTIONS GIVEN TO YOU BY YOUR DOCTOR. They may differ from the information contained in this leaflet. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed ANASTROZOLE-SYNTHON for another reason. ANA Perskaitykite visą dokumentą
ANASTROZOLE-SYNTHON PRODUCT INFORMATION FEBRUARY 2011 Page 1 of 13 ANASTROZOLE-SYNTHON FILM-COATED TABLETS (anastrozole) PRODUCT INFORMATION NAME OF THE MEDICINE _ _ Anastrozole _ _ Chemical name: α,α,α’,α’-tetramethyl-5-(1_H_-1,2,4-triazol-1-ylmethyl)-1,3- benzenediacetonitrile. Molecular formula: C17H19N5 Molecular weight: 293.37 Structural formula: CAS: 120511-73-1. DESCRIPTION ANASTROZOLE-SYNTHON is a fine white to off-white powder. It is slightly soluble (1.8 mg/mL at 23 °C) which is independent of pH. ANASTROZOLE-SYNTHON is a white, film-coated, round, biconvex tablet, debossed with “ANA” and “1” on one side containing 1 mg anastrozole and includes the following excipients: Lactose, povidone, sodium starch glycollate, magnesium stearate, hypromellose, macrogol 400, titanium dioxide (E171). PHARMACOLOGY Anastrozole is a potent and highly selective nonsteroidal aromatase inhibitor. It significantly lowers serum oestradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone. Many breast cancers have oestrogen receptors and growth of these tumours can be stimulated by oestrogen. In postmenopausal women, oestradiol is produced primarily from the conversion of androstenedione to oestrone through the aromatase enzyme complex in peripheral tissues. Oestrone is subsequently converted to oestradiol. CN CH 3 CH 3 NC CH 3 H 3 C N N N ANASTROZOLE-SYNTHON PRODUCT INFORMATION Perskaitykite visą dokumentą