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ANASTROZOLE-SYNTHON CMI
FEBRUARY 2011
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ANASTROZOLE-SYNTHON
Anastrozole
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some of the common questions people ask about ANASTROZOLE-
SYNTHON. It does not contain all the available information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor will have weighed
the risks of you taking it
against the benefits they expect it will have for you.
IF YOU HAVE
ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT ANASTROZOLE-SYNTHON IS USED FOR
ANASTROZOLE-SYNTHON is used to treat breast cancer in women who no longer have
their menstrual periods either naturally, due to their age or after surgery, radiotherapy or
chemotherapy.
It is a non-steroidal aromatase inhibitor, which reduces the amount of oestrogen (female sex
hormone) made by the body. In some types of breast cancer, oestrogen can help the cancer
cells grow. By blocking oestrogen, ANASTROZOLE-SYNTHON may slow or stop the growth
of cancer.
FOLLOW ALL DIRECTIONS GIVEN TO YOU BY YOUR DOCTOR.
They may differ from the information contained
in this leaflet.
ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS
ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have
prescribed ANASTROZOLE-SYNTHON for another reason.
ANA
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ANASTROZOLE-SYNTHON PRODUCT INFORMATION FEBRUARY 2011
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ANASTROZOLE-SYNTHON FILM-COATED TABLETS
(anastrozole)
PRODUCT INFORMATION
NAME OF THE MEDICINE
_ _
Anastrozole
_ _
Chemical name: α,α,α’,α’-tetramethyl-5-(1_H_-1,2,4-triazol-1-ylmethyl)-1,3-
benzenediacetonitrile.
Molecular formula: C17H19N5
Molecular weight: 293.37
Structural formula:
CAS: 120511-73-1.
DESCRIPTION
ANASTROZOLE-SYNTHON is a fine white to off-white powder. It is slightly soluble
(1.8 mg/mL at 23 °C) which is independent of pH.
ANASTROZOLE-SYNTHON is a white, film-coated, round, biconvex tablet,
debossed with “ANA” and “1” on one side containing 1 mg anastrozole and includes
the following excipients: Lactose, povidone, sodium starch glycollate, magnesium
stearate, hypromellose, macrogol 400, titanium dioxide (E171).
PHARMACOLOGY
Anastrozole is a potent and highly selective nonsteroidal aromatase inhibitor. It
significantly lowers serum oestradiol concentrations and has no detectable effect on
formation of adrenal corticosteroids or aldosterone.
Many breast cancers have oestrogen receptors and growth of these tumours can be
stimulated by oestrogen. In postmenopausal
women, oestradiol is produced primarily
from the conversion of androstenedione to oestrone through the aromatase enzyme
complex in peripheral tissues. Oestrone is subsequently converted to oestradiol.
CN
CH
3
CH
3
NC
CH
3
H
3
C
N
N
N
ANASTROZOLE-SYNTHON PRODUCT INFORMATION
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