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ZOVIRAX
®
_200 MG DISPERSIBLE TABLETS_
_aciclovir_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about ZOVIRAX. It does
not contain all of the available
information.
Reading this leaflet does not take the
place of talking to your doctor or
pharmacist.
Taking any medicine involves some
risk. It is possible that all risks
associated with this medicine might
not have been detected, despite
proper testing. Only your doctor or
pharmacist is able to weigh up all of
the relevant facts, and you should
consult them if you have any queries.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING ZOVIRAX ASK YOUR DOCTOR
OR PHARMACIST.
KEEP THIS INFORMATION.
You may want to read it again.
This leaflet provides information
about ZOVIRAX. The statements
that are made in this leaflet cannot be
applied to any other medicine, even
those that are similar or appear to
contain the same ingredients.
WHAT ZOVIRAX IS
USED FOR
ZOVIRAX is used for the treatment
and management of genital herpes.
_HOW DOES ZOVIRAX WORK?_
Aciclovir (the active ingredient in
ZOVIRAX) belongs to a group of
medicines called "anti-virals".
ZOVIRAX works by stopping the
production of the herpes virus. This
reduces the length and severity of an
outbreak of herpes. ZOVIRAX can
also be taken long term to reduce the
number of herpes outbreaks in people
who experience this condition often.
ZOVIRAX does not get rid of the
virus from your body.
Your doctor may, however, have
prescribed ZOVIRAX for a different
use to that described above.
IF YOU HAVE ANY QUESTIONS ABOUT
WHY YOU ARE TAKING ZOVIRAX ASK
YOUR DOCTOR OR PHARMACIST.
Your doctor or pharmacist will be
able to provide you with more
information.
BEFORE YOU TAKE
ZOVIRAX
ZOVIRAX IS NOT SUITABLE FOR
EVERYONE.
BE SURE THAT YOUR DOCTOR KNOWS
ABOUT THE FOLLOWING BEFORE YOU TAKE
ZOVIRAX:
1.
IF YOU ARE ALLERGIC TO:
•
Aciclovir (the active ingredient in
ZOVIRAX) or valaciclovir.
•
Any other ingredient listed at the
end of this leaflet.
2.
IF YOU ARE PREGNANT, OR BECOME
PREGNANT WHILE
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ZOVIRAX
®
TABLETS AND ZOVIRAX
®
DISPERSIBLE TABLETS
NAME OF THE DRUG:
Aciclovir
_Chemical name:_ 9-((2-hydroxyethoxy)methyl)guanine
_Chemical Structure _
N
HN
N
N
O
H
2
N
O
HO
_ _
_CAS Number_: 59277-89-3
DESCRIPTION:
Aciclovir is a synthetic acyclic purine nucleoside analogue. It is a
white crystalline powder slightly
soluble in water and practically insoluble in most organic solvents.
The chemical structure of
aciclovir is:
Each Zovirax tablet contains 200 mg, 400 mg or 800 mg of aciclovir.
Zovirax Dispersible Tablets (200 mg, 400 mg and 800 mg) contain the
excipients cellulose-
microcrystalline, aluminium magnesium silicate, sodium starch
glycollate, povidone, magnesium
stearate, Opadry Complete film coating system White Y-1-7000 and
macrogol 8000.
Zovirax 200 mg Tablets contain the excipients
cellulose-microcrystalline, lactose monohydrate,
magnesium stearate, povidone and sodium starch glycollate.
Zovirax 400 mg and 800 mg Tablets contain the excipients
cellulose-microcrystalline, magnesium
stearate, povidone and sodium starch glycollate.
PHARMACOLOGY:
MICROBIOLOGY:
Aciclovir is an antiviral agent which is active _in vitro_ against
_Herpes simplex_ virus (HSV) types I
and II
and
_Varicella _
_zoster_
virus (VZV),
the
latter
being
considerably
less sensitive.
The
relationship between the level of _ in vitro_ sensitivity of herpes
viruses to aciclovir and clinical
response to therapy has not been adequately established. Development
of resistance by HSV to
aciclovir has been documented. Aciclovir needs to be phosphorylated to
the active compound,
aciclovir triphosphate, in order to become active against the virus.
Such conversion is very limited
in normal cells and in addition cellular DNA polymerase is not very
sensitive to the active
compound. However,
in infected cells HSV or VZV-coded thymidine kinase facilitates the
conversion
of
aciclovir
to
aciclovir
monophosphate
which
is
then
converted
to
aciclovir
2
triphosphate by cellular enzymes. Aciclovir triphosphate acts as an
inhibitor of, and substrate for
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