Country: Ավստրալիա
language: անգլերեն
source: Department of Health (Therapeutic Goods Administration)
aciclovir
GlaxoSmithKline Australia Pty Ltd
Registered
ZOVIRAX ® _200 MG DISPERSIBLE TABLETS_ _aciclovir_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about ZOVIRAX. It does not contain all of the available information. Reading this leaflet does not take the place of talking to your doctor or pharmacist. Taking any medicine involves some risk. It is possible that all risks associated with this medicine might not have been detected, despite proper testing. Only your doctor or pharmacist is able to weigh up all of the relevant facts, and you should consult them if you have any queries. IF YOU HAVE ANY CONCERNS ABOUT TAKING ZOVIRAX ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS INFORMATION. You may want to read it again. This leaflet provides information about ZOVIRAX. The statements that are made in this leaflet cannot be applied to any other medicine, even those that are similar or appear to contain the same ingredients. WHAT ZOVIRAX IS USED FOR ZOVIRAX is used for the treatment and management of genital herpes. _HOW DOES ZOVIRAX WORK?_ Aciclovir (the active ingredient in ZOVIRAX) belongs to a group of medicines called "anti-virals". ZOVIRAX works by stopping the production of the herpes virus. This reduces the length and severity of an outbreak of herpes. ZOVIRAX can also be taken long term to reduce the number of herpes outbreaks in people who experience this condition often. ZOVIRAX does not get rid of the virus from your body. Your doctor may, however, have prescribed ZOVIRAX for a different use to that described above. IF YOU HAVE ANY QUESTIONS ABOUT WHY YOU ARE TAKING ZOVIRAX ASK YOUR DOCTOR OR PHARMACIST. Your doctor or pharmacist will be able to provide you with more information. BEFORE YOU TAKE ZOVIRAX ZOVIRAX IS NOT SUITABLE FOR EVERYONE. BE SURE THAT YOUR DOCTOR KNOWS ABOUT THE FOLLOWING BEFORE YOU TAKE ZOVIRAX: 1. IF YOU ARE ALLERGIC TO: • Aciclovir (the active ingredient in ZOVIRAX) or valaciclovir. • Any other ingredient listed at the end of this leaflet. 2. IF YOU ARE PREGNANT, OR BECOME PREGNANT WHILE read_full_document
1 ZOVIRAX ® TABLETS AND ZOVIRAX ® DISPERSIBLE TABLETS NAME OF THE DRUG: Aciclovir _Chemical name:_ 9-((2-hydroxyethoxy)methyl)guanine _Chemical Structure _ N HN N N O H 2 N O HO _ _ _CAS Number_: 59277-89-3 DESCRIPTION: Aciclovir is a synthetic acyclic purine nucleoside analogue. It is a white crystalline powder slightly soluble in water and practically insoluble in most organic solvents. The chemical structure of aciclovir is: Each Zovirax tablet contains 200 mg, 400 mg or 800 mg of aciclovir. Zovirax Dispersible Tablets (200 mg, 400 mg and 800 mg) contain the excipients cellulose- microcrystalline, aluminium magnesium silicate, sodium starch glycollate, povidone, magnesium stearate, Opadry Complete film coating system White Y-1-7000 and macrogol 8000. Zovirax 200 mg Tablets contain the excipients cellulose-microcrystalline, lactose monohydrate, magnesium stearate, povidone and sodium starch glycollate. Zovirax 400 mg and 800 mg Tablets contain the excipients cellulose-microcrystalline, magnesium stearate, povidone and sodium starch glycollate. PHARMACOLOGY: MICROBIOLOGY: Aciclovir is an antiviral agent which is active _in vitro_ against _Herpes simplex_ virus (HSV) types I and II and _Varicella _ _zoster_ virus (VZV), the latter being considerably less sensitive. The relationship between the level of _ in vitro_ sensitivity of herpes viruses to aciclovir and clinical response to therapy has not been adequately established. Development of resistance by HSV to aciclovir has been documented. Aciclovir needs to be phosphorylated to the active compound, aciclovir triphosphate, in order to become active against the virus. Such conversion is very limited in normal cells and in addition cellular DNA polymerase is not very sensitive to the active compound. However, in infected cells HSV or VZV-coded thymidine kinase facilitates the conversion of aciclovir to aciclovir monophosphate which is then converted to aciclovir 2 triphosphate by cellular enzymes. Aciclovir triphosphate acts as an inhibitor of, and substrate for read_full_document