국가: 미국
언어: 영어
출처: NLM (National Library of Medicine)
Trimethoprim (UNII: AN164J8Y0X) (Trimethoprim - UNII:AN164J8Y0X), Sulfadiazine (UNII: 0N7609K889) (Sulfadiazine - UNII:0N7609K889)
Neogen Corporation
ORAL
PRESCRIPTION
UNIPRIM POWDER FOR HORSES is indicated in horses where potent systemic antibacterial action against sensitive organisms is required. UNIPRIM POWDER FOR HORSES is indicated where control of bacterial infections is required during treatment of: UNIPRIM POWDER FOR HORSES is well tolerated by foals. Trimethoprim and sulfadiazine should not be used in horses showing marked liver parenchymal damage, blood dyscrasias, or in those with history of sulfonamide sensitivity.
UNIPRIM POWDER FOR HORSES is available in 37.5 g packets, 200 g jars, 400 g jars, 2000 g pails. Apple Flavored UNIPRIM POWDER FOR HORSES is available in 37.5 g packets, 200 g jars, 400 g jars, 1200 g jars, and 2000 g pails.
Abbreviated New Animal Drug Application
UNIPRIM- TRIMETHOPRIM AND SULFADIAZINE POWDER NEOGEN CORPORATION ---------- UNIPRIM POWDER FOR HORSES DESCRIPTION UNIPRIM POWDER FOR HORSES contains 67 mg trimethoprim and 333 mg sulfadiazine per gram. UNIPRIM POWDER FOR HORSES is a combination of trimethoprim and sulfadiazine in the ratio of 1 part to 5 parts by weight, which provides effective antibacterial activity against a wide range of bacterial infections in animals. Trimethoprim is 2, 4 diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine. ACTIONS _Microbiology:_ Trimethoprim blocks bacterial production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. Sulfadiazine, in common with other sulfonamides, inhibits bacterial synthesis of dihydrofolic acid by competing with _para_-aminobenzoic acid. Trimethoprim and sulfadiazine thus imposes a sequential double blockade on bacterial metabolism. This deprives bacteria of nucleic acids and proteins essential for survival and multiplication, and produces a high level of antibacterial activity which is usually bactericidal. Although both sulfadiazine and trimethoprim are antifolate, neither affects the folate metabolism of animals. The reasons are: animals do not synthesize folic acid and cannot, therefore, be directly affected by sulfadiazine; and although animals must reduce their dietary folic acid to tetrahydrofolic acid, trimethoprim does not affect this reduction because its affinity for dihydrofolate reductase of mammals is significantly less than for the corresponding bacterial enzyme. Trimethoprim and sulfadiazine is active against a wide spectrum of bacterial pathogens, both gram-negative and gram-positive. The following _in vitro_ data are available, but their clinical significance is unknown. In general, species of the following genera are sensitive to trimethoprim and sulfadiazine: VERY SENSITIVE SENSITIVE MODERATELY SENSITIVE NOT SENSITIVE _Escherichia_ _Staphylococcus_ _Moraxella_ _Mycobacterium_ _Streptococcus_ _Neisseria_ _Nocardia_ _ 전체 문서 읽기