UNIPRIM- trimethoprim and sulfadiazine powder

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

Trimethoprim (UNII: AN164J8Y0X) (Trimethoprim - UNII:AN164J8Y0X), Sulfadiazine (UNII: 0N7609K889) (Sulfadiazine - UNII:0N7609K889)

Available from:

Neogen Corporation

Administration route:

ORAL

Prescription type:

PRESCRIPTION

Therapeutic indications:

UNIPRIM POWDER FOR HORSES is indicated in horses where potent systemic antibacterial action against sensitive organisms is required. UNIPRIM POWDER FOR HORSES is indicated where control of bacterial infections is required during treatment of: UNIPRIM POWDER FOR HORSES is well tolerated by foals. Trimethoprim and sulfadiazine should not be used in horses showing marked liver parenchymal damage, blood dyscrasias, or in those with history of sulfonamide sensitivity.

Product summary:

UNIPRIM POWDER FOR HORSES is available in 37.5 g packets, 200 g jars, 400 g jars, 2000 g pails. Apple Flavored UNIPRIM POWDER FOR HORSES is available in 37.5 g packets, 200 g jars, 400 g jars, 1200 g jars, and 2000 g pails.

Authorization status:

Abbreviated New Animal Drug Application

Summary of Product characteristics

UNIPRIM- TRIMETHOPRIM AND SULFADIAZINE POWDER
NEOGEN CORPORATION
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UNIPRIM POWDER FOR HORSES
DESCRIPTION
UNIPRIM POWDER FOR HORSES contains 67 mg trimethoprim and 333 mg
sulfadiazine
per gram.
UNIPRIM POWDER FOR HORSES is a combination of trimethoprim and
sulfadiazine in the
ratio of 1 part to 5 parts by weight, which provides effective
antibacterial activity against
a wide range of bacterial infections in animals.
Trimethoprim is 2, 4 diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine.
ACTIONS
_Microbiology:_ Trimethoprim blocks bacterial production of
tetrahydrofolic acid from
dihydrofolic acid by binding to and reversibly inhibiting the enzyme
dihydrofolate
reductase.
Sulfadiazine, in common with other sulfonamides, inhibits bacterial
synthesis of
dihydrofolic acid by competing with _para_-aminobenzoic acid.
Trimethoprim and sulfadiazine thus imposes a sequential double
blockade on bacterial
metabolism. This deprives bacteria of nucleic acids and proteins
essential for survival
and multiplication, and produces a high level of antibacterial
activity which is usually
bactericidal.
Although both sulfadiazine and trimethoprim are antifolate, neither
affects the folate
metabolism of animals. The reasons are: animals do not synthesize
folic acid and cannot,
therefore, be directly affected by sulfadiazine; and although animals
must reduce their
dietary folic acid to tetrahydrofolic acid, trimethoprim does not
affect this reduction
because its affinity for dihydrofolate reductase of mammals is
significantly less than for
the corresponding bacterial enzyme.
Trimethoprim and sulfadiazine is active against a wide spectrum of
bacterial pathogens,
both gram-negative and gram-positive. The following _in vitro_ data
are available, but their
clinical significance is unknown. In general, species of the following
genera are sensitive
to trimethoprim and sulfadiazine:
VERY SENSITIVE
SENSITIVE
MODERATELY SENSITIVE
NOT SENSITIVE
_Escherichia_
_Staphylococcus_
_Moraxella_
_Mycobacterium_
_Streptococcus_
_Neisseria_
_Nocardia_
_