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STILDEM- Consumer Medicine Information
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STILDEM
zolpidem tartrate
CONSUMER MEDICINE INFORMATION (CMI)
WARNING: ZOLPIDEM MAY BE ASSOCIATED WITH UNUSUAL AND POTENTIALLY DANGEROUS BEHAVIOURS
WHILST APPARENTLY ASLEEP. THESE HAVE INCLUDED SLEEP WALKING, DRIVING MOTOR VEHICLES AND OTHER
BIZARRE BEHAVIOURS. SOME MEDICINES MAY INTERACT WITH ZOLPIDEM AND PARTICULAR CAUTION IS
NEEDED WITH OTHER DRUGS THAT MAY ALSO ACT ON THE BRAIN; BEFORE YOU TAKE ZOLPIDEM REFER TO THE
"TAKING OTHER MEDICINES" SECTION BELOW OR ASK YOUR DOCTOR OR PHARMACIST. YOU MUST NOT DRINK
ALCOHOL WHEN YOU TAKE ZOLPIDEM. DO NOT TAKE ZOLPIDEM FOR MORE THAN 4 WEEKS. IF YOUR SLEEP
PROBLEMS CONTINUE, CONSULT YOUR DOCTOR.
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about STILDEM.
It does not contain all of the
available information. It does not
take the place of talking to your
doctor or pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking STILDEM against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, TALK TO
YOUR DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT STILDEM IS USED
FOR
STILDEM is used to initiate and
maintain sleep in those with
sleeping difficulties, also called
insomnia.
STILDEM works by binding to
special sites in the brain which
produce sleep. It has a different
chemical structure to other sleeping
tablets.
In general, sleeping tablets such as
STILDEM are not recommended for
use for more than 4 weeks at a
time.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS AB
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STILDEM- Product Information
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STILDEM
PRODUCT INFORMATION
ZOLPIDEM MAY BE ASSOCIATED WITH POTENTIALLY DANGEROUS COMPLEX SLEEP-RELATED
BEHAVIOURS WHICH MAY INCLUDE SLEEP WALKING, SLEEP DRIVING AND OTHER BIZARRE
BEHAVIOURS. ZOLPIDEM IS NOT TO BE TAKEN WITH ALCOHOL. CAUTION IS NEEDED WITH OTHER
CNS DEPRESSANT DRUGS. LIMIT USE TO FOUR WEEKS MAXIMUM UNDER CLOSE MEDICAL
SUPERVISION.
NAME OF THE MEDICINE
Zolpidem tartrate The chemical name of zolpidem tartrate is 2-(4-methylphenyl)- N,N,6-
trimethylimidazo [1,2,a] pyridine-3-acetamide hemitartrate.
Its structural formula is:
(C
19
H
21
N
3
O)
2
, C
4
H
6
O
6
Molecular weight: 764.9
CAS No.: 99294-93-6
DESCRIPTION
Zolpidem tartrate is a white to off-white colourless, hygroscopic, crystalline powder, slightly soluble
in water.
STILDEM tablets come in one strength and contain 10 mg of zolpidem tartrate. The tablets also
contain the following excipients: lactose, microcrystalline cellulose, sodium starch glycollate,
purified
talc, magnesium stearate, hypromellose, hydroxypropylcellulose and titanium dioxide. The tablets
are gluten free.
PHARMACOLOGY
Zolpidem belongs to the imidazopyridine group of compounds and is structurally unrelated to other
hypnotic agents. Zolpidem selectively binds the omega-1 receptor subtype (also known as the
benzodiazepine-1 subtype) which is the alpha unit of the GABA-A receptor complex. Whereas
benzodiazepines non-selectively bind all three omega receptor subtypes, zolpidem preferentially
binds the omega-1 subtype. The modulation of the chloride anion cha
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