국가: 말레이시아
언어: 영어
출처: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ALBENDAZOLE
Pelangi Vet Pharma Sdn. Bhd.
ALBENDAZOLE
1.00 mcg/mL; 5.00 mcg/mL; 10.00 mcg/mL
Pelangi Vet Pharma Sdn. Bhd.
PDP-ALBENDAZOLE SUSPENSION COMPOSITION: EACH LITER CONTAINS. Albendazole BP Vet 19.00 gm _PRESERVATIVE: _ Sodium Methyl Paraben BP 0.2 % Sodium Propyl Paraben BP 0.02 % Sodium Benzoate BP 0.2 % DESCRIPTION: A light orange coloured suspension PHARMACOLOGY: Albendazole’s mode of actionhas been shown to be based on the inhibition of the uptake and efficiency of utilization of glucose by roundworms and tapeworms and similar activity is presumed in liver fluke Albendazole mode of action is to inhibit energy metabolism by uncoupling phosphorylation reactions. In fasciola hepatica, cellular changes due to Alebendazole include deformed mitochondria, dilatation of the rough endoplasmic reticulum, vesiculation of the golgi field and a reduction or absence of secretary granules. PHARMACOKINETICS: The pharmacokinetics of albendazole and the same as when the products are administered separately. Peak plasma levels are attained 15 hours after treatment. The depletion curve is linear and indicates a drug half-life 10 hours. Albendazole absorbed from the gut and rapidly metabolized in the liver almost completely to the 2- amino sulfone metabolite plus 3 o 4 other metabolites. Peak plasma albendazole levels are reached within 8 to 24 hours. Due to plasma binding, levels persist which are adequate to exert a sustained anthelminitic effect on Haemonchus contortus. Tissue residues, however, are minimal. Albendazole is metabolized primarily in the liver and, due to concentration in the bile, excretion of metabolites is largely via the faecal route. INDICATIONS: Control of susceptible mature and immature gastrointestinal roundworms, large lung worms, liver fluke, nasal bots; reduces output of viable worm and fluke eggs and provides sustained control of barber’s pole worm in sheep. Control of the following albendazole sensitive stomach. intestinal and bowel worms: barber's pole worm (Haemonch us contortus), stomach hair worm (Trichostrongylus axei), black scour worm (Trichostrongylus sp.), small brown stomach worm (Ostertagia sp.), 전체 문서 읽기