국가: 말레이시아
언어: 영어
출처: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
SILDENAFIL CITRATE
Noripharma Sdn. Bhd.
SILDENAFIL CITRATE
2tablet Tablets; 2tablet Tablets; 4tablet Tablets
Noripharma Sdn. Bhd.
_CONSUMER MEDICATION INFORMATION LEAFLET_ VIAGRIL 50MG TABLET / VIAGRIL 100MG TABLET SILDENAFIL CITRATE 50MG & 100MG Page | 1 WHAT IS IN THIS LEAFLET: 1. What VIAGRIL is used for 2. How VIAGRIL works 3. Before you use VIAGRIL 4. How to use VIAGRIL 5. While you are using it 6. Side effects 7. Storage and Disposal of VIAGRIL. 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision 1. WHAT VIAGRIL IS USED FOR VIAGRIL is indicated for the treatment of erectile dysfunction sometimes known as impotence, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. VIAGRIL will only help to get an erection if you are sexually stimulated. You should not take VIAGRIL if you are women. 2. HOW VIAGRIL WORKS VIAGRIL belongs to a group of medicines called phosphodiesterase type 5 inhibitors. It works by helping to relax the blood vessels in your penis, allowing blood to flow into your penis when you get sexually excited. _What VIAGRIL does not do_ It does not cure erectile dysfunction. It is a treatment for erectile dysfunction. VIAGRIL does not protect you or your partner from sexually transmitted disease. VIAGRIL is not a hormone or an aphrodisiac (a substance that stimulates sexual desire_)_. 3. BEFORE YOU TAKE VIAGRIL _When you must not take it_ If you are allergic to sildenafil or any other ingredients of VIAGRIL. If you have severe heart or liver problem. If you take VIAGRIL while taking nitrates, the combined effect of the VIAGRIL and the nitrates can lower your blood pressure to such an extent that it could prove fatal. Never take VIAGRIL at the same time as taking nitrates. If you have ever had loss of vision caused by non-arteritic anterior ischaemic optic neuropathy (NAION), a cause of decreased vision or loss of vision. _Before you start to take it._ Inform your doctor if you have Sickle cell anemia (an abnormality of red blood cells), leukemia, multiple myeloma (cancer of bone marrow). Deformi 전체 문서 읽기
1 MAXEFIL TABLET DESCRIPTION: MAXEFIL 100MG TABLET: A blue coloured diamond shaped film coated tablet with score on one side MAXEFIL 50MG TABLET: A blue coloured diamond shaped film coated tablet with score on one side COMPOSITION: Each film coated tablet contains 50 or 100mg Sildenafil (as the citrate salt). PHARMACODYNAMIC: Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)- specific phosphodiesterase type 5 (PDE5). It is used as an oral therapy for erectile dysfunction. The mechanism of erection involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. Nitric Oxide activates the enzymes guanylate cyclase. This will result in increased levels of cGMP which produces smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Sildenafil enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood to the corpus cavernosum. It has no effect in the absence of sexual stimulation. PHARMACOKINETICS: _ Absorption_: Sildenafil is rapidly absorbed after oral administration. Nonetheless, only about 40% of a dose reaches systemic circulation unchanged. Within 30 – 120 minutes peak plasma concentration usually will be attained. High fat meals delays GI absorption, peak plasma concentrations are reduced by about 30% and time to peak plasma concentration delayed about 60min. _ Distribution_: N-desmethyl metabolite and Sildenafil are bound to plasma proteins. Protein binding is independent of total drug concentration. _ Metabolism_: It undergoes extensive metabolism in GI mucosa during absorption and on first pass through liver. Sildenafil is metabolized in the liver principally by CYP3A4 and to lesser extent by CYP2C9.The major circulating metabolites results from N-demethylation of sildenafil, and itself further metabolized. _Elimination_: Sildenafil is excreted as metabolites mainly in the faece 전체 문서 읽기