DIAMICRON MR TABLET 60mg
국가: 싱가포르
언어: 영어
출처: HSA (Health Sciences Authority)
환자 정보 전단 유효 성분:
gliclazide
제공처:
SERVIER (S) PTE LTD
ATC 코드:
A10BB09
복용량:
60mg
약제 형태:
TABLET, FILM COATED, EXTENDED RELEASE
구성:
gliclazide 60mg
관리 경로:
ORAL
처방전 유형:
Prescription Only
Manufactured by:
LES LABORATOIRES SERVIER INDUSTRIE
승인 상태:
ACTIVE
승인 날짜:
2010-09-22
환자 정보 전단
PRODUCT INFORMATION
DIAMICRON® MR
MODIFIED RELEASE TABLETS
GLICLAZIDE
NAME OF THE DRUG
_DIAMICRON_® _MR 30 MG: _gliclazide 30mg modified
release tablet blister pack
_DIAMICRON_® _MR 60MG: _gliclazide 60 mg modified release
tablet blister pack
DESCRIPTION
_DIAMICRON_® _MR _30 mg and _DIAMICRON_® _MR _60mg are modified
release formulations.
Active Ingredient
Gliclazide is a
white or almost white powder, practically insoluble in
water, freely soluble in
dichloromethane, sparingly soluble in acetone and
slightly soluble in ethanol 96%. The melting point of
gliclazide is approximately 168°C.
_Chemical Name
: _1-(3-azabicyclo[3.3.0]oct-3-yl)-3-_p_-tolylsulfonylurea
_Molecular Formula _: C
15
H
21
N
3
O
3
S
_Chemical Structure _:
Excipients
_DIAMICRON®_ _MR 30MG: _Calcium hydrogen phosphate, maltodextrin, hypromellose, magnesium
stearate and silica–colloidal anhydrous.
_DIAMICRON_® _MR 60MG: _Lactose
monohydrate, maltodextrin, hypromellose, magnesium stearate
and silica–colloidal anhydrous.
PHARMACOLOGY
Gliclazide is an oral hypoglycaemic sulfonylurea which differs from other related
compounds. It has an
N-containing heterocyclic ring with an endocyclic bond.
Gliclazide reduces blood glucose levels by stimulating insulin
secretion from the
β-cells of the islets of
Langerhans. Gliclazide shows high affinity, strong selectivity and
reversible binding to the
β-cell K
ATP
channels with a low affinity for cardiac and vascular K
ATP
channels. Increased postprandial insulin and
C-peptide secretion
persists after two years of treatment. Gliclazide also
has extra-pancreatic effects
and haemovascular properties.
Effects on insulin release
In type II diabetes, gliclazide restores the
first peak of insulin secretion in response to glucose and
increases the s
전체 문서 읽기
제품 특성 요약
PRODUCT INFORMATION
DIAMICRON® MR
MODIFIED RELEASE TABLETS
GLICLAZIDE
NAME OF THE DRUG
_DIAMICRON_® _MR 30MG: _gliclazide 30mg modified release tablet
blister pack
_DIAMICRON_® _MR 60MG: _gliclazide 60mg modified release tablet
blister pack
DESCRIPTION
_ _
_DIAMICRON_® _MR 30MG_ and _DIAMICRON_® _MR 60MG_ are modified
release formulations.
Active Ingredient
Gliclazide is a white or almost white powder, practically insoluble in
water, freely soluble in
dichloromethane, sparingly soluble in acetone and slightly soluble in
ethanol 96%. The melting point of
gliclazide is approximately 168°C.
_Chemical Name :
_1-(3-azabicyclo[3.3.0]oct-3-yl)-3-_p_-tolylsulfonylurea
_Molecular Formula _: C
15
H
21
N
3
O
3
S
_Chemical Structure _:
Excipients
_DIAMICRON®_ _MR 30MG: _Calcium hydrogen phosphate, maltodextrin,
hypromellose, magnesium
stearate and silica–colloidal anhydrous.
_DIAMICRON_® _MR 60MG: _Lactose monohydrate, maltodextrin,
hypromellose, magnesium stearate
and silica–colloidal anhydrous.
PHARMACOLOGY
Gliclazide is an oral hypoglycaemic sulfonylurea which differs from
other related compounds. It has an
N-containing heterocyclic ring with an endocyclic bond.
Gliclazide reduces blood glucose levels by stimulating insulin
secretion from the β-cells of the islets of
Langerhans. Gliclazide shows high affinity, strong selectivity and
reversible binding to the β-cell K
ATP
channels with a low affinity for cardiac and vascular K
ATP
channels. Increased postprandial insulin and
C-peptide secretion persists after two years of treatment. Gliclazide
also has extra-pancreatic effects
and haemovascular properties.
Effects on insulin release
In type II diabetes, gliclazide restores the first peak of insulin
secretion in response to glucose and
increases the second phase of insulin secretion. A significant
increase in insulin release is seen in
response to stimulation induced by a meal or glucose.
Extra-pancreatic effects
Gliclazide has been shown to increase peripheral insulin sensitivity:
•
In muscle, euglycaemic h
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