Negara: Singapura
Bahasa: Inggris
Sumber: HSA (Health Sciences Authority)
gliclazide
SERVIER (S) PTE LTD
A10BB09
60mg
TABLET, FILM COATED, EXTENDED RELEASE
gliclazide 60mg
ORAL
Prescription Only
LES LABORATOIRES SERVIER INDUSTRIE
ACTIVE
2010-09-22
PRODUCT INFORMATION DIAMICRON® MR MODIFIED RELEASE TABLETS GLICLAZIDE NAME OF THE DRUG _DIAMICRON_® _MR 30 MG: _gliclazide 30mg modified release tablet blister pack _DIAMICRON_® _MR 60MG: _gliclazide 60 mg modified release tablet blister pack DESCRIPTION _DIAMICRON_® _MR _30 mg and _DIAMICRON_® _MR _60mg are modified release formulations. Active Ingredient Gliclazide is a white or almost white powder, practically insoluble in water, freely soluble in dichloromethane, sparingly soluble in acetone and slightly soluble in ethanol 96%. The melting point of gliclazide is approximately 168°C. _Chemical Name : _1-(3-azabicyclo[3.3.0]oct-3-yl)-3-_p_-tolylsulfonylurea _Molecular Formula _: C 15 H 21 N 3 O 3 S _Chemical Structure _: Excipients _DIAMICRON®_ _MR 30MG: _Calcium hydrogen phosphate, maltodextrin, hypromellose, magnesium stearate and silica–colloidal anhydrous. _DIAMICRON_® _MR 60MG: _Lactose monohydrate, maltodextrin, hypromellose, magnesium stearate and silica–colloidal anhydrous. PHARMACOLOGY Gliclazide is an oral hypoglycaemic sulfonylurea which differs from other related compounds. It has an N-containing heterocyclic ring with an endocyclic bond. Gliclazide reduces blood glucose levels by stimulating insulin secretion from the β-cells of the islets of Langerhans. Gliclazide shows high affinity, strong selectivity and reversible binding to the β-cell K ATP channels with a low affinity for cardiac and vascular K ATP channels. Increased postprandial insulin and C-peptide secretion persists after two years of treatment. Gliclazide also has extra-pancreatic effects and haemovascular properties. Effects on insulin release In type II diabetes, gliclazide restores the first peak of insulin secretion in response to glucose and increases the s Baca dokumen lengkapnya
PRODUCT INFORMATION DIAMICRON® MR MODIFIED RELEASE TABLETS GLICLAZIDE NAME OF THE DRUG _DIAMICRON_® _MR 30MG: _gliclazide 30mg modified release tablet blister pack _DIAMICRON_® _MR 60MG: _gliclazide 60mg modified release tablet blister pack DESCRIPTION _ _ _DIAMICRON_® _MR 30MG_ and _DIAMICRON_® _MR 60MG_ are modified release formulations. Active Ingredient Gliclazide is a white or almost white powder, practically insoluble in water, freely soluble in dichloromethane, sparingly soluble in acetone and slightly soluble in ethanol 96%. The melting point of gliclazide is approximately 168°C. _Chemical Name : _1-(3-azabicyclo[3.3.0]oct-3-yl)-3-_p_-tolylsulfonylurea _Molecular Formula _: C 15 H 21 N 3 O 3 S _Chemical Structure _: Excipients _DIAMICRON®_ _MR 30MG: _Calcium hydrogen phosphate, maltodextrin, hypromellose, magnesium stearate and silica–colloidal anhydrous. _DIAMICRON_® _MR 60MG: _Lactose monohydrate, maltodextrin, hypromellose, magnesium stearate and silica–colloidal anhydrous. PHARMACOLOGY Gliclazide is an oral hypoglycaemic sulfonylurea which differs from other related compounds. It has an N-containing heterocyclic ring with an endocyclic bond. Gliclazide reduces blood glucose levels by stimulating insulin secretion from the β-cells of the islets of Langerhans. Gliclazide shows high affinity, strong selectivity and reversible binding to the β-cell K ATP channels with a low affinity for cardiac and vascular K ATP channels. Increased postprandial insulin and C-peptide secretion persists after two years of treatment. Gliclazide also has extra-pancreatic effects and haemovascular properties. Effects on insulin release In type II diabetes, gliclazide restores the first peak of insulin secretion in response to glucose and increases the second phase of insulin secretion. A significant increase in insulin release is seen in response to stimulation induced by a meal or glucose. Extra-pancreatic effects Gliclazide has been shown to increase peripheral insulin sensitivity: • In muscle, euglycaemic h Baca dokumen lengkapnya