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Albumex 20 AU CMI 10.00
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ALBUMEX
®
20_ _
Human albumin, solution for intravenous infusion
Consumer Medicine Information
10 ML AUST R 31820
100 ML AUST R 46283
WHAT IS IN THIS LEAFLET?
This leaflet answers some
common questions about
Albumex
®
20. It does not contain
all the available information
about Albumex
®
20. It does NOT
take the place of talking to your
doctor.
All medicines have benefits and
risks. Your doctor has weighed
the benefits that Albumex
®
20
will have for you against the
risks.
IF YOU HAVE ANY CONCERNS
ABOUT USING THIS MEDICINE, ASK
YOUR DOCTOR. FOLLOW YOUR
DOCTOR'S ADVICE EVEN IF IT IS
DIFFERENT FROM WHAT THIS LEAFLET
SAYS.
PLEASE READ THIS LEAFLET
CAREFULLY AND KEEP IT FOR FUTURE
REFERENCE. The information in
this leaflet is subject to change.
Please check with your doctor
whether there is any new
information about this medicine
that you should know since you
were last treated with this
medicine.
WHAT ALBUMEX
®
20 IS
USED FOR
Albumex
®
20 may be used:
• in an acutely ill patient
when the amount of
protein in their blood is
low (hypoproteinaemia)
• to replace fluid in the
blood vessels due to
acute loss of blood or
plasma (plasma is the
non-cellular part of the
blood)
• to treat extensive burns
• to treat a serious lung
condition (respiratory
distress syndrome)
• in procedures where the
patient’s blood is purified
(haemodialysis)
• in procedures where the
patient’s plasma is
replaced (plasma
exchange).
The main functions of Albumex
®
20 are to replace and retain fluid
in the blood vessels and to carry
other chemicals through the
blood stream.
ASK YOUR DOCTOR IF YOU HAVE
ANY QUESTIONS ABOUT WHY
ALBUMEX
®
20 HAS BEEN
PRESCRIBED FOR YOU.
BEFORE
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Albumex 20 AU PI 10.00
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Product Information
ALBUMEX
®
20
HUMAN ALBUMIN 20% (200 G/L)
AUSTRALIA
NAME OF THE MEDICINE
Human albumin, solution for intravenous infusion.
DESCRIPTION
Albumex
®
20 is manufactured from human plasma collected by the
Australian Red Cross
Blood Service. Albumex
®
20 is a clear, slightly viscous liquid;
it is almost colourless, yellow,
amber or green. It is prepared using predominantly
chromatographic techniques. It is a sterile,
preservative-free 20% w/v human albumin
solution. It is hyperoncotic and hypo-osmotic
compared to human serum. It has a nominal osmolality of 130 mOsm/kg, is hypotonic and the
pH is 6.7 to 7.3. The manufacturing process for Albumex
®
20 contains dedicated steps to
reduce the possibility of virus transmission including
pasteurisation (heating at 60°C for 10
hours) and incubation at low pH to inactivate viruses. The
composition of Albumex
®
20 is as
follows:
Human Albumin
200 g/L
Sodium
48 – 100 mmol/L
Octanoate
32 mmol/L
PHARMACOLOGY
Albumin accounts quantitatively for more than half of the
total protein in the plasma and
represents about 10% of the protein synthesis activity
of the liver. The metabolic half-life of
albumin _in vivo_ is about 19 days and the turnover in an
adult is approximately 15 g per day.
There is rapid interchange of albumin between
the intra and extravascular spaces.
Albumex
®
20 has two main functions: maintenance of plasma
colloid osmotic pressure and
carriage of intermediate products in the
transport and exchange of tissue metabolites.
The beneficial effect of human albumin for fluid resuscitation is thought to result principally
from its contribution to colloid osmotic pressure (i.e. oncotic
pressure).
Albumex
®
20 is hyperoncotic with hum
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