theophylline- Theophylline, anhydrous liquid

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

theophylline, anhydrous (UNII: 0I55128JYK) (theophylline, anhydrous - UNII:0I55128JYK)

から入手可能:

Actavis Mid Atlantic LLC

INN（国際名）:

Theophylline, anhydrous

医薬品形態:

LIQUID

構図:

80 mg in 15 mL

投与経路:

ORAL

処方タイプ:

PRESCRIPTION DRUG

適応症:

Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis. Theophylline Elixir is contraindicated in patients with a history of hypersensitivity to theophylline or other components in the product.

製品概要:

Theophylline Elixir, 80 mg/15 mL with 20% alcohol, is a fruit-flavored reddish-orange liquid available in one pint (473 mL) and one gallon (3785 mL) bottles. Store at controlled room temperature 15º-30ºC (59º-86ºF). Do not refrigerate. Dispense in a tight, light-resistant container as defined in the USP. CAUTION: Federal law prohibits dispensing without prescription. Manufactured by Barre-National Inc. Baltimore, MD 21244 an ALPHARMA USPD company Form No. 1444 Rev. 1/97 C1 VC1299

製品の特徴

THEOPHYLLINE- THEOPHYLLINE, ANHYDROUS LIQUID
ACTAVIS MID ATLANTIC LLC
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THEOPHYLLINE ELIXIR
FORM NO. 1444
DESCRIPTION
THEOPHYLLINE IS STRUCTURALLY CLASSIFIED AS A METHYLXANTHINE. IT OCCURS
AS A WHITE, ODORLESS,
CRYSTALLINE POWDER WITH A BITTER TASTE. ANHYDROUS THEOPHYLLINE HAS THE
CHEMICAL NAME 1H-PURINE-
2,6-DIONE,3,7-DIHYDRO-1,3-DIMETHYL-, AND IS REPRESENTED BY THE
FOLLOWING STRUCTURAL FORMULA:
The molecular formula of anhydrous theophylline is C H N O with a
molecular weight of 180.17.
Theophylline Elixir is available as a liquid intended for oral
administration, containing 80 mg of
anhydrous theophylline and 20% alcohol per 15 mL (one tablespoonful).
Also contains: FD&C Red #40, Artificial Mixed Fruit Flavor, Propylene
Glycol, Purified Water,
Saccharin Sodium. May contain Citric Acid to adjust pH.
CLINICAL PHARMACOLOGY
MECHANISM OF ACTION:
Theophylline has two distinct actions in the airways of patients with
reversible obstruction; smooth
muscle relaxation (i.e., bronchodilation) and suppression of the
response of the airways to stimuli (i.e.,
non-bronchodilator prophylactic effects). While the mechanisms of
action of theophylline are not
known with certainty, studies in animals suggest that
bronchodilatation is mediated by the inhibition of
two isozymes of phosphodiesterase (PDE III and, to a lesser extent,
PDE IV) while non-bronchodilator
prophylactic actions are probably mediated through one or more
different molecular mechanisms, that
do not involve inhibition of PDE III or antagonism of adenosine
receptors. Some of the adverse effects
associated with theophylline appear to be mediated by inhibition of
PDE III (e.g., hypotension,
tachycardia, headache, and emesis) and adenosine receptor antagonism
(e.g., alterations in cerebral
blood flow).
Theophylline increases the force of contraction of diaphragmatic
muscles. This action appears to be
due to enhancement of calcium uptake through an adenosine-mediated
channel.
SERUM CONCENTRATION-EFFECT RELATIONSHIP:
Bronchodilation occurs over the serum theop