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TERRY WHITE CHEMISTS
INDAPAMIDE
_Contains the active ingredient, indapamide hemihydrate (pronounced
ind-ap-a-mide)_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about indapamide. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is Terry
White Chemists Indapamide. It
contains the active ingredient,
indapamide hemihydrate.
It is used either alone or with other
medicines to treat:
•
mild to moderate hypertension
(high blood pressure).
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HOW IT WORKS_
Indapamide, at a dose of 2.5 mg, is
thought to lower blood pressure by
relaxing some of the blood vessels in
the body. The blood vessels can then
carry the same volume of blood more
easily. It is not fully understood how
it exactly does this.
Indapamide can be used alone or in
combination with other medicines to
lower blood pressure.
Everyone has blood pressure. This
pressure helps get your blood all
around your body. Your blood
pressure may be different at different
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製品の特徴
Product Information – Australia
Terry White Chemists Indapamide Tablets
Page 1
TERRY WHITE CHEMISTS INDAPAMIDE
NAME OF THE MEDICINE
Indapamide hemihydrate.
Chemical Name:
Indapamide hemihydrate
is 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl benzamide
hemihydrate.
Chemical Structure:
Molecular Formula:
C
16
H
16
CIN
3
O
3
S, ½ H
2
O
Molecular weight:
374.85.
CAS Registry Number: 26807-65-8.
DESCRIPTION
Indapamide hemihydrate is a nonthiazide indole derivative
of chlorosulfonamide. It is a white crystalline
lipophilic powder, soluble in methanol, ethanol, acetic acid and
ethyl acetate, very slightly soluble in ether,
chloroform and benzene and practically insoluble in water. Melting
point: approximately 185°C.
PHARMACOLOGY
PHARMACODYNAMICS
Indapamide is an oral antihypertensive agent. The
mechanism whereby indapamide exerts its
antihypertensive action has not been completely elucidated; both vascular and renal actions have been
implicated.
At a dose of 2.5 mg the renal effects of indapamide are
minimal and the antihypertensive effect of
indapamide has been attributed to a reduction in vascular reactivity to pressor amines. The finding that
indapamide retains its antihypertensive activity in
functionally anephric patients lends support to the
hypothesis.
The renal site of action of indapamide is the proximal segment of the
distal tubule. Indapamide appears
to have natriuretic properties (sodium and chloride being
excreted in equivalent amounts) with less effect
on kaliuresis or uric acid excretion. Only at doses greater than 2.5 mg/day is an appreciable increase in
urinary volume observed in humans. No significant changes in
plasma sodium levels have been
observed in clinical studies. Significant hypokalaemia (plasma
potassium < 3.2 mmol/L
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