ROMPUN- xylazine injection, solution

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

XYLAZINE (UNII: 2KFG9TP5V8) (XYLAZINE - UNII:2KFG9TP5V8)

から入手可能:

Bayer HealthCare, LLC

INN（国際名）:

XYLAZINE

構図:

XYLAZINE 100 mg in 1 mL

投与経路:

INTRAMUSCULAR

処方タイプ:

PRESCRIPTION

適応症:

Rompun® (xylazine injection) should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia. Horses: Rompun® (xylazine injection) has been used successfully as follows: Cervidae : Rompun® (xylazine injection) may be used for the following: Rompun® at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine.

製品概要:

Rompun® (xylazine injection) 100 mg/mL Injection for intravenous or intramuscular use is available in 50 mL multiple dose vials.

認証ステータス:

New Animal Drug Application

製品の特徴

ROMPUN- XYLAZINE INJECTION, SOLUTION
BAYER HEALTHCARE, LLC
----------
ROMPUN
(XYLAZINE INJECTION)
100 MG/ML
SEDATIVE AND ANALGESIC FOR USE IN HORSES
AND _CERVIDAE_ ONLY
DESCRIPTION:
Rompun (xylazine injection) is supplied in 50 mL multiple dose vials
as a sterile solution.
Each mL contains 100 mg Rompun (xylazine base equivalent); 0.9 mg
methylparaben;
0.1 mg propylparaben; water for injection; citric acid and sodium
citrate for pH
adjustment to 5.5 ± 0.3.
ACTIVE INGREDIENT:
xylazine
hydrochloride...........................................................
11.4%
(Equivalent to 10% base)
INERT
INGREDIENTS:...........................................................
88.6%
100.0%
CAUTION:
Federal (U.S.A.) law restricts this drug to use by or on the order of
a licensed
veterinarian. Do not use in _Cervidae_ less than 15 days before or
during the hunting
season.
PHARMACOLOGY:
Rompun , a non-narcotic compound, is a sedative and analgesic as well
as muscle
relaxant. Its sedative and analgesic activity is related to central
nervous system
depression. Its muscle-relaxant effect is based on inhibition of the
intraneural
transmission of impulses in the central nervous system. The principal
pharmacological
activities develop within 10 to 15 minutes after intramuscular
injection, and within 3 to 5
minutes following intravenous administration in horses.
A sleeplike state, the depth of which is dose-dependent, is usually
maintained for 1 to 2
hours, while analgesia lasts from 15 to 30 minutes. The
centrally-acting muscle relaxant
effect causes relaxation of the skeletal musculature, complementing
sedation and
analgesia.
In horses and _Cervidae_ under the influence of Rompun the respiratory
rate is reduced
as in natural sleep. Following treatment with Rompun the heart rate is
decreased and a
transient change in the conductivity of the cardiac muscle may occur,
as evidenced by a
partial atrioventricular block. This resembles the atrioventricular
block often observed in
normal horses.
Although a partial A-V block may occasionally o