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RAPIFEN
®
1
RAPIFEN
®
_Alfentanil Hydrochloride Injection (equivalent to 0.5 mg/mL
alfentanil) _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions people ask about
Rapifen. It does not contain all the
information that is known about
Rapifen .
It does not take the place of talking to
your doctor, anaesthetist or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you being given Rapifen
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
BEING GIVEN THIS MEDICINE, ASK YOUR
DOCTOR, ANAESTHETIST OR PHARMACIST.
KEEP THIS LEAFLET. YOU MAY NEED TO
READ IT AGAIN.
WHAT RAPIFEN IS FOR
Rapifen is a drug used to relieve pain
and produce anaesthesia.
It can be used as a premedication
before an operation, or with a general
anaesthetic during an operation.
Rapifen belongs to a group of
medicines called opioid (narcotic)
analgesics.
Rapifen works by changing the
messages that are sent to the brain
about pain.
Your doctor will have explained why
you are being treated with Rapifen
and told you what dose you will be
given.
Follow all directions given to you by
your doctor carefully. They may
differ from the information contained
in this leaflet.
Your doctor may prescribe this
medicine for another use. Ask your
doctor if you want more information.
Rapifen can be addictive, but when it
is used only to relieve or prevent pain
it is unlikely to become habit
forming.
BEFORE YOU ARE GIVEN
RAPIFEN
_WHEN YOU MUST NOT USE IT _
RAPIFEN SHOULD NOT BE USED FOR
PAIN RELIEF AFTER SURGERY HAS TAKEN
PLACE.
RAPIFEN IS NOT GENERALLY GIVEN TO
CHILDREN UNDER 12 YEARS.
YOU SHOULD NOT BE GIVEN RAPIFEN IF
YOU ARE PREGNANT OR BREASTFEEDING
UNLESS YOUR DOCTOR SAYS IT IS SAFE.
AS
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製品の特徴
CCDS080511 1
RAPIFEN(111124)API
RAPIFEN
®
INJECTION
PRODUCT INFORMATION
NAME OF THE MEDICINE
Alfentanil Hydrochloride (equivalent to 0.5mg/mL alfentanil)
DESCRIPTION
RAPIFEN (alfentanil hydrochloride) is a potent short-acting
narcotic analgesic for
intravenous use by anaesthetists.
It is available as a sterile solution of alfentanil hydrochloride
equivalent to 0.5mg/mL
alfentanil with 9.0mg sodium chloride in water for Injection to
1mL.
Alfentanil
hydrochloride
CAS No: 71195-58-9
PHARMACOLOGY
_PHARMACODYNAMICS _
Alfentanil is a potent, short-acting opioid analgesic chemically
related to fentanyl.
The onset of action of alfentanil is more rapid than that of an
equianalgesic dose of
fentanyl, and the maximal analgesic and respiratory depressant effect
occurs within 1
to 2 minutes. The time to onset of analgesia was 55.7 (range 15
-120) seconds for
alfentanil, compared to 103.8 (range 30 -120) seconds for
fentanyl. Depth of analgesia
can be adjusted to the pain level of the surgical procedure.
The duration of action of alfentanil is shorter than that of an
equianalgesic dose of
fentanyl, and is dose-related. Durations of action for short,
medium and long
procedures are discussed under "DOSAGE AND ADMINISTRATION". For
analgesia
lasting longer than 60 minutes, an infusion is preferable.
.HCl
CCDS080511 2
RAPIFEN(111124)API
The duration of the analgesic effect may be shorter than that of the
respiratory
depression, in some patients. The duration and degree of apnoea,
respiratory
depression and increased airway resistance usually increase with
dose but have also
been observed at lower doses (see "PRECAUTIONS"). The
time course of respiratory
depression is not related to the pharmacokinetics described below.
At higher doses (>120micrograms/kg) alfentanil can be used as an
anaesthetic
induction agent. Induction is smooth
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