OXYBUTYNIN CHLORIDE solution

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

OXYBUTYNIN CHLORIDE (UNII: L9F3D9RENQ) (OXYBUTYNIN - UNII:K9P6MC7092)

から入手可能:

Qualitest Pharmaceuticals

INN（国際名）:

OXYBUTYNIN CHLORIDE

構図:

OXYBUTYNIN CHLORIDE 5 mg in 5 mL

処方タイプ:

PRESCRIPTION DRUG

認証ステータス:

Abbreviated New Drug Application

製品の特徴

OXYBUTYNIN CHLORIDE- OXYBUTYNIN CHLORIDE SOLUTION
QUALITEST PHARMACEUTICALS
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OXYBUTYNIN CHLORIDE SYRUP (OXYBUTYNIN CHLORIDE ORAL SOLUTION, USP 5
MG PER 5 ML)
RX ONLY
DESCRIPTION
Each 5 mL of oxybutynin chloride syrup (oxybutynin chloride oral
solution) contains 5 mg of
oxybutynin chloride, USP.
Chemically, oxybutynin chloride is d,l (racemic)
4-diethylamino-2-butynyl phenylcyclohexylglycolate
hydrochloride. The empirical formula of oxybutynin chloride is C
H NO •HCl. The structural
formula appears below:
Oxybutynin chloride is a white crystalline solid with a molecular
weight of 393.9. It is readily soluble
in water and acids, but relatively insoluble in alkalis.
Oxybutynin Chloride Syrup (Oxybutynin Chloride Oral Solution) also
contains: Apple-Watermelon
flavor, citric acid, FD&C Green #3, glycerin, methylparaben, purified
water, sodium citrate, sorbitol
solution, and sucrose.
Oxybutynin Chloride Syrup (Oxybutynin Chloride Oral Solution) is for
oral administration.
Therapeutic Category: Antispasmodic, anticholinergic.
CLINICAL PHARMACOLOGY
Oxybutynin chloride exerts a direct antispasmodic effect on smooth
muscle and inhibits the muscarinic
action of acetylcholine on smooth muscle. Oxybutynin chloride exhibits
only one-fifth of the
anticholinergic activity of atropine on the rabbit detrusor muscle,
but four to ten times the antispasmodic
activity. No blocking effects occur at skeletal neuromuscular
junctions or autonomic ganglia
(antinicotinic effects).
Oxybutynin chloride relaxes bladder smooth muscle. In patients with
conditions characterized by
involuntary bladder contractions, cystometric studies have
demonstrated that oxybutynin chloride
increases bladder (vesical) capacity, diminishes the frequency of
uninhibited contractions of the
detrusor muscle, and delays the initial desire to void. Oxybutynin
chloride thus decreases urgency and
the frequency of both incontinent episodes and voluntary urination.
Antimuscarinic activity resides predominately in the R-isomer. A
metabolite, desethyloxybutynin,