NU-PROPAFENONE TABLET

国: カナダ

言語: 英語

ソース: Health Canada

有効成分:

PROPAFENONE HYDROCHLORIDE

から入手可能:

NU-PHARM INC

ATCコード:

C01BC03

INN（国際名）:

PROPAFENONE

投薬量:

150MG

医薬品形態:

TABLET

構図:

PROPAFENONE HYDROCHLORIDE 150MG

投与経路:

ORAL

パッケージ内のユニット:

100

処方タイプ:

Prescription

治療領域:

CLASS IC ANTIARRYTHMICS

製品概要:

Active ingredient group (AIG) number: 0116258001; AHFS:

認証ステータス:

CANCELLED (UNRETURNED ANNUAL)

承認日:

2018-03-28

製品の特徴

PRODUCT MONOGRAPH
NU-PROPAFENONE
PROPAFENONE HYDROCHLORIDE TABLETS
150 MG
ANTIARRHYTHMIC AGENT
NU-PHARM INC.
DATE OF PREPARATION:
50 MURAL STREET, UNITS 1&2
February 11, 2003
RICHMOND HILL, ONTARIO
L4B 1E4
_Control # 089683_
1
PRODUCT MONOGRAPH
NU-PROPAFENONE
Propafenone Hydrochloride Tablets
150 mg
THERAPEUTIC CLASSIFICATION
Antiarrhythmic Agent
A
CTIONS AND CLINICAL PHARMACOLOGY
Mechanism of Action
Propafenone is an antiarrhythmic agent which possesses class Ic
properties in the modified
electrophysiological classification of Vaughan-Williams. It has a
direct stabilizing action on
myocardial cell membranes. The electrophysiological effect of
propafenone manifests itself as a
reduction of the upstroke velocity (Phase 0) of the monophasic action
potential, while phase 4
spontaneous automaticity is depressed. Diastolic excitability
threshold is increased and effective
refractory period prolonged. In Purkinje fibers, and to a lesser
extent myocardial fibers,
propafenone reduces the fast inward sodium current.
In addition to a local anesthetic effect, approximately equal to
procaine, propafenone has weak
beta-blocking activity. Clinical trials employing isoproterenol
challenge and exercise testing
suggest that the affinity of propafenone for beta-adrenergic
receptors, as calculated from dose
ratios and drug concentrations, is about 1/40 that of propranolol.
Propafenone also inhibits the
slow calcium influx at high concentrations; however, this action is
weak (approximately 1/100 of
verapamil) and does not contribute to its antiarrhythmic effect.
2
Electrophysiology
Electrophysiology studies have shown that propafenone prolongs
atrioventricular conduction and
in some instances significantly lengthens sinus nodal recovery times
with a non-significant effect
on sinus cycle length. AV nodal conduction time (AH interval) as well
as His-Purkinje conduction
time (HV interval) are prolonged. Propafenone increases atrial, AV
nodal and ventricular
effective refractory periods. Propafenone causes a dose-dependent
increase in t