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Naltrexone GH
Version 2
– (RD dd Nov 2012)
1
NALTREXONE GH
CONSUMER MEDICINE INFORMATION
WHAT IS THIS LEAFLET?
This leaflet answers some common
questions about Naltrexone GH. It
does not contain all of the available
information.
All medicines have risks and benefits.
Your doctor has weighed the risks of
your taking Naltrexone GH against the
benefits they expect it will have for
you. If you have any concerns about
taking Naltrexone GH, ask your doctor
or pharmacist.
Keep this leaflet with the medicine.
You may want to read it again.
WHAT IS NALTREXONE GH USED FOR?
Naltrexone GH is used to help opiate
drug addicts kick the habit. It is also
used to help alcoholics dry out and
remain abstinent.
Naltrexone GH tablets contain the
active ingredient, naltrexone
hydrochloride. It is an opiate
antagonist. This means it fights the
effects of opiate drugs like heroin on
the body, and blocks euphoria (or
“high”) due to these opiates.
Your doctor may have prescribed
Naltrexone GH for another use. Ask
your doctor if you have any questions
about why Naltrexone GH has been
prescribed for you.
Naltrexone GH is not addictive.
BEFORE YOU TAKE NALTREXONE GH
Naltrexone GH is not suitable for
everyone.
_WHEN YOU MUST NOT TAKE IT_
Do not take Naltrexone GH if you
have had an allergic reaction to
Naltrexone GH or any of the
ingredients.
Symptoms of an allergic reaction
may include, but are not limited to,
swelling of the face or tongue,
difficulty in breathing, wheezing or
an itchy skin rash.
DO NOT TAKE NALTREXONE GH IF
YOU ARE STILL USING HEROIN OR
DRUGS LIKE IT.
If you take Naltrexone GH right
after taking an opiate you will
suffer withdr
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製品の特徴
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Naltrexone GH
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PRODUCT INFORMATION
NALTREXONE GH
NAME OF MEDICINE
Naltrexone Hydrochloride
• HCl
O
HO
N-CH
2
OH
H
O
naltrexone hydrochloride
The CAS Registry Number of naltrexone hydrochloride is 16676-29-2.
DESCRIPTION
Naltrexone hydrochloride, an opioid antagonist, is a synthetic congener of oxymorphone with no opioid
agonist properties. Naltrexone differs in structure from oxymorphone in that the methyl group on the nitrogen
atom is replaced by a cyclopropylmethyl group. Naltrexone hydrochloride is also related to the potent opioid
antagonist, naloxone, or n-allylnoroxymorphone [NARCAN® (naloxone hydrochloride)]. The chemical
name of naltrexone hydrochloride is 17-(cyclopropylmethyl)-4,5
-epoxy-3,14-dihydroxymorphinan-6-one
hydrochloride.
Naltrexone hydrochloride is a white, crystalline compound. The hydrochloride salt is soluble in water to the
extent of about 100 mg/mL. Naltrexone GH is available in scored tablets containing 50 mg of naltrexone
hydrochloride.
Naltrexone GH also contains lactose, microcrystalline cellulose, powdered cellulose, silica-colloidal
anhydrous, magnesium stearate, crospovidone, hypromellose, macrogol 4000, titanium dioxide, iron oxide
black, iron oxide red and iron oxide yellow.
PHARMACOLOGY
PHARMACODYNAMIC PROPERTIES
Naltrexone hydrochloride is a pure opioid antagonist. It markedly attenuates or completely blocks, reversibly,
the subjective effects of all opioids.
When co-administered with morphine, on a chronic basis, naltrexone hydrochloride blocks the physical
dependence to morphine, heroin and other opioids.
Naltrexone has few, if any, intrinsic actions besides its opioid blocking properties. However, it does produce
some pupillary constriction, by an unknown m
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