国: カナダ
言語: 英語
ソース: Health Canada
MORPHINE SULFATE
ETHYPHARM INC
N02AA01
MORPHINE
60MG
CAPSULE (EXTENDED RELEASE)
MORPHINE SULFATE 60MG
ORAL
20/50
Narcotic (CDSA I)
OPIATE AGONISTS
Active ingredient group (AIG) number: 0104545010; AHFS:
APPROVED
2006-04-07
_N_ _M-ESLON_ _® _ _(morphine sulfate) Product Monograph _ PRODUCT MONOGRAPH N M-ESLON ® (Morphine Sulfate) 10 mg, 15 mg, 30 mg, 60 mg, 100 mg, 200 mg Extended Release Capsules Narcotic Analgesic Ethypharm Inc. 1000 de la Gauchetière Ouest, Suite 2400 Date of Revision: June 11, 2019 Montréal, Québec, H3B 4W5 Submission Control No. 226278 _ _ _N_ _M-ESLON_ _® _ _(morphine sulfate) Product Monograph _ _Page 2 of 38 _ ACTIONS Morphine is a narcotic analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO 2 , nausea and vomiting via stimulation of the CTZ, changes in mood including euphoria and dysphoria, sedation, mental clouding, and alterations of the endocrine and autonomic nervous systems. The psychological effects are of longer duration than that of analgesia. Morphine-induced analgesia is relatively selective in that other sensory modalities (touch, vision, hearing) are not affected. Moderate doses of morphine are effective in relieving clinical (pathological) pain and increasing pain threshold to tolerate pain. The capacity to perceive the sensation of pain may be relatively unaltered. The analgesic effects of morphine are due to its CNS action, i.e., limbic system, hypothalamus, and centrally induced endocrinological effect. At present, the exact mechanism by which the opiates exert their effects remains unknown. Morphine is readily absorbed from the gastrointestinal tract and after s.c. or i.m. injection. Due to first-pass metabolism in the liver, the effect of an oral dose is less than after parenteral administration. With repeated regular dosing, orally administered morphine is about one-third as potent as when given by i.m. injection. Morphine is primarily excreted in the urine as morphine- 3- glucuronide. Abou 完全なドキュメントを読む