LIDOCAINE HYDROCHLORIDE- lidocaine hydrochloride anhydrous injection, solution

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

LIDOCAINE HYDROCHLORIDE ANHYDROUS (UNII: EC2CNF7XFP) (LIDOCAINE - UNII:98PI200987)

から入手可能:

Spectra Medical Devices, LLC

INN（国際名）:

LIDOCAINE HYDROCHLORIDE ANHYDROUS

構図:

LIDOCAINE HYDROCHLORIDE ANHYDROUS 10 mg in 1 mL

投与経路:

EPIDURAL

処方タイプ:

PRESCRIPTION DRUG

適応症:

Lidocaine HCl is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.

製品概要:

Lidocaine Hydrochloride Injection, USP is supplied as follows: Single Dose Ampule (box of 25) All solutions should be stored at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light. Manufactured for: Spectra Medical Devices, LLC. Wilmington, MA 01887 Manufactured by: Huons Co., Ltd., Seoul, S. Korea Product Code: 1605-1 Revised: 03/2018

認証ステータス:

Abbreviated New Drug Application

製品の特徴

LIDOCAINE HYDROCHLORIDE- LIDOCAINE HYDROCHLORIDE ANHYDROUS INJECTION,
SOLUTION
SPECTRA MEDICAL DEVICES, LLC
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LIDOCAINE HYDROCHLORIDE INJECTION, USP
SPL UNCLASSIFIED SECTION
For Infiltration and Nerve Block Rx only
DESCRIPTION
Lidocaine Hydrochloride Injection, USP is a sterile, nonpyrogenic,
aqueous solution that
contains a local anesthetic agent and is administered parenterally by
injection. See
INDICATIONS for specific uses.
The solution contains lidocaine HCl, which is chemically designated as
acetamide, 2-
(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride and has the
molecular wt.
270.8. Lidocaine HCl (C14H22N2O • HCl) has the following structural
formula:
Lidocaine Hydrochloride Injection, USP single dose solutions are
methylparaben free.
Lidocaine Hydrochloride Injection, USP is a sterile, nonpyrogenic,
isotonic solution
containing sodium chloride. The pH of this solution is adjusted to
approximately 6.5 (5.0
to 7.0) with sodium hydroxide and/or hydrochloric acid.
CLINICAL PHARMACOLOGY:
MECHANISM OF ACTION:
Lidocaine HCl stabilizes the neuronal membrane by inhibiting the ionic
fluxes required for
the initiation and conduction of impulses thereby effecting local
anesthetic action.
HEMODYNAMICS:
Excessive blood levels may cause changes in cardiac output, total
peripheral resistance,
and mean arterial pressure. With central neural blockade these changes
may be
attributable to block of autonomic fibers, a direct depressant effect
of the local
anesthetic agent on various components of the cardiovascular system,
and/or the beta-
adrenergic receptor stimulating action of epinephrine when present.
The net effect is
normally a modest hypotension when the recommended dosages are not
exceeded.
PHARMACOKINETICS AND METABOLISM:
Information derived from diverse formulations, concentrations and
usages reveals that
lidocaine HCl is completely absorbed following parenteral
administration, its rate of
absorption depending, for example, upon various factors such as the
site of
administration and the presen