LASIX furosemide tablet

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

furosemide (UNII: 7LXU5N7ZO5) (furosemide - UNII:7LXU5N7ZO5)

から入手可能:

Sanofi-Aventis U.S. LLC

INN（国際名）:

furosemide

構図:

furosemide 20 mg

処方タイプ:

PRESCRIPTION DRUG

認証ステータス:

New Drug Application

製品の特徴

LASIX- FUROSEMIDE TABLET
SANOFI-AVENTIS U.S. LLC
----------
LASIX
(FUROSEMIDE)
TABLETS 20, 40, AND 80 MG
WARNING
LASIX (FUROSEMIDE) IS A POTENT DIURETIC WHICH, IF GIVEN IN EXCESSIVE
AMOUNTS, CAN LEAD TO A
PROFOUND DIURESIS WITH WATER AND ELECTROLYTE DEPLETION. THEREFORE,
CAREFUL MEDICAL SUPERVISION IS
REQUIRED AND DOSE AND DOSE SCHEDULE MUST BE ADJUSTED TO THE INDIVIDUAL
PATIENT'S NEEDS. (SEE
DOSAGE AND ADMINISTRATION.)
DESCRIPTION
LASIX is a diuretic which is an anthranilic acid derivative. LASIX
tablets for oral administration
contain furosemide as the active ingredient and the following inactive
ingredients: lactose monohydrate
NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon
dioxide NF. Chemically, it is 4-
chloro-N-furfuryl-5-sulfamoylanthranilic acid. LASIX is available as
white tablets for oral
administration in dosage strengths of 20, 40 and 80 mg. Furosemide is
a white to off-white odorless
crystalline powder. It is practically insoluble in water, sparingly
soluble in alcohol, freely soluble in
dilute alkali solutions and insoluble in dilute acids.
The CAS Registry Number is 54-31-9.
The structural formula is as follows:
CLINICAL PHARMACOLOGY
Investigations into the mode of action of LASIX have utilized
micropuncture studies in rats, stop flow
experiments in dogs and various clearance studies in both humans and
experimental animals. It has been
demonstrated that LASIX inhibits primarily the absorption of sodium
and chloride not only in the
proximal and distal tubules but also in the loop of Henle. The high
degree of efficacy is largely due to
the unique site of action. The action on the distal tubule is
independent of any inhibitory effect on
carbonic anhydrase and aldosterone.
Recent evidence suggests that furosemide glucuronide is the only or at
least the major
biotransformation product of furosemide in man. Furosemide is
extensively bound to plasma proteins,
mainly to albumin. Plasma concentrations ranging from 1 to 400 μg/mL
are 91 to 99% bound in healthy
individuals. The unboun